Gély, C.A., Huesca, A., Picard-Hagen N., Toutain P.L., Berrebi, A., Gauderat, G., Gayrard, V., Lacroix, M.Z., 2021. A new LC/MS method for specific determination of human systemic exposure to bisphenol A, F and S through their metabolites: Application to cord blood samples. Environment International 151: 106429.

Moreau, J., Gatimel, N., Lippi, Y., Tavenier, G., Fauque, P., Guilleman, M., Naylies, C., Huesca, A.A., Gayrard, V., Parinaud, J., Leandri, R.D., 2021. Impact of the polycarbonate strippers used in assisted reproduction techniques on embryonic development. Hum Reprod 36: 331-339.


Babajko, S., Gayrard, V., Houari, S., Thu Bui, A., Barouki, R., Niederreither, K., Fini, J.-B., Dursun, E., Coumoul, X., 2020. Oral cavity as a target and a marker of environmental exposures: developmental dental defects. Med Sci (Paris) 36, 225–230.

Gayrard, V., Lacroix, M.Z., Gély, C.A., Grandin, F.C., Léandri, R., Bouchard, M., Roques, B., Toutain, P.-L., Picard-Hagen, N., 2020. Toxicokinetics of bisphenol S in rats for predicting human bisphenol S clearance from allometric scaling. Toxicol Appl Pharmacol 386, 114845.

Guillard, A., Gaultier, E., Cartier, C., Devoille, L., Noireaux, J., Chevalier, L., Morin, M., Grandin, F., Lacroix, M.Z., Coméra, C., Cazanave, A., de Place, A., Gayrard, V., Bach, V., Chardon, K., Bekhti, N., Adel-Patient, K., Vayssière, C., Fisicaro, P., Feltin, N., de la Farge, F., Picard-Hagen, N., Lamas, B., Houdeau, E., 2020. Basal Ti level in the human placenta and meconium and evidence of a materno-foetal transfer of food-grade TiO2 nanoparticles in an ex vivo placental perfusion model. Part Fibre Toxicol 17, 51.

Khmiri, I., Côté, J., Mantha, M., Khemiri, R., Lacroix, M., Gely, C., Toutain, P.-L., Picard-Hagen, N., Gayrard, V., Bouchard, M., 2020. Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data. Environ Int 138, 105644.

Klement, W., Oliviero, F., Gangarossa, G., Zub, E., De Bock, F., Forner-Piquer, I., Blaquiere, M., Lasserre, F., Pascussi, J.-M., Maurice, T., Audinat, E., Ellero-Simatos, S., Gamet-Payrastre, L., Mselli-Lakhal, L., Marchi, N., 2020. Life-long Dietary Pesticide Cocktail Induces Astrogliosis Along with Behavioral Adaptations and Activates p450 Metabolic Pathways. Neuroscience 446, 225–237.

Metsu, D., Lanot, T., Fraissinet, F., Concordet, D., Gayrard, V., Averseng, M., Ressault, A., Martin-Blondel, G., Levade, T., Février, F., Chatelut, E., Delobel, P., Gandia, P., 2020. Comparing ultrafiltration and equilibrium dialysis to measure unbound plasma dolutegravir concentrations based on a design of experiment approach. Sci Rep 10, 12265.

Oliviero, F., Lukowicz, C., Boussadia, B., Forner-Piquer, I., Pascussi, J.-M., Marchi, N., Mselli-Lakhal, L., 2020. Constitutive Androstane Receptor: A Peripheral and a Neurovascular Stress or Environmental Sensor. Cells 9.

Smith, L., Klément, W., Dopavogui, L., de Bock, F., Lasserre, F., Barretto, S., Lukowicz, C., Fougerat, A., Polizzi, A., Schaal, B., Patris, B., Denis, C., Feuillet, G., Canlet, C., Jamin, E.L., Debrauwer, L., Mselli-Lakhal, L., Loiseau, N., Guillou, H., Marchi, N., Ellero-Simatos, S., Gamet-Payrastre, L., 2020. Perinatal exposure to a dietary pesticide cocktail does not increase susceptibility to high-fat diet-induced metabolic perturbations at adulthood but modifies urinary and fecal metabolic fingerprints in C57Bl6/J mice. Environ Int 144, 106010.

Viguié, C., Chaillou, E., Gayrard, V., Picard-Hagen, N., Fowler, P.A., 2020. Toward a better understanding of the effects of endocrine disrupting compounds on health: Human-relevant case studies from sheep models. Mol Cell Endocrinol 505, 110711.

Martin, P.G.P., Dupouy, V., Leghait, J., Pineau, T., Polizzi, A., Lasserre, F., Roques, B.B., Viguié C., 2020. Transcriptomic modifications of the thyroid gland upon exposure to phytosanitary-grade fipronil: Evidence for the activation of compensatory pathways. Toxicol Appl Pharmacol 389:114873. https://doi: 10.1016/j.taap.2019.114873. 

Viguié, C., Zalko, D. The trouble with endocrine disruptors, 2020. Mol Cell Endocrinol 513:110874. https://doi: 10.1016/j.mce.2020.110874.



Barretto, S.A., Lasserre, F., Fougerat, A., Smith, L., Fougeray, T., Lukowicz, C., Polizzi, A., Smati, S., Régnier, M., Naylies, C., Bétoulières, C., Lippi, Y., Guillou, H., Loiseau, N., Gamet-Payrastre, L., Mselli-Lakhal, L., Ellero-Simatos, S., 2019. Gene Expression Profiling Reveals that PXR Activation Inhibits Hepatic PPARα Activity and Decreases FGF21 Secretion in Male C57Bl6/J Mice. Int J Mol Sci 20.

Deceuninck, Y., Bichon, E., Gény, T., Veyrand, B., Grandin, F., Viguié, C., Marchand, P., Le Bizec, B., 2019. Quantitative method for conjugated metabolites of bisphenol A and bisphenol S determination in food of animal origin by Ultra High Performance Liquid Chromatography-Tandem Mass Spectrometry. J Chromatogr A 1601, 232–242.

Gayrard, V., Lacroix, M.Z., Grandin, F.C., Collet, S.H., Mila, H., Viguié, C., Gély, C.A., Rabozzi, B., Bouchard, M., Léandri, R., Toutain, P.-L., Picard-Hagen, N., 2019. Oral Systemic Bioavailability of Bisphenol A and Bisphenol S in Pigs. Environ. Health Perspect. 127, 77005.

Grandin, F.C., Gayrard, V., Picard-Hagen, N., Toutain, P.-L., 2019. Comment on “Toxicokinetics of bisphenol A, bisphenol S, and bisphenol F in a pregnancy sheep model.” Chemosphere 227, 703–704.

Grandin, F.C., Lacroix, M.Z., Gayrard, V., Viguié, C., Mila, H., de Place, A., Vayssière, C., Morin, M., Corbett, J., Gayrard, C., Gely, C.A., Toutain, P.-L., Picard-Hagen, N., 2019. Is bisphenol S a safer alternative to bisphenol A in terms of potential fetal exposure ? Placental transfer across the perfused human placenta. Chemosphere 221, 471–478.

Lukowicz, C., Ellero-Simatos, S., Régnier, M., Oliviero, F., Lasserre, F., Polizzi, A., Montagner, A., Smati, S., Boudou, F., Lenfant, F., Guzylack-Pirou, L., Menard, S., Barretto, S., Fougerat, A., Lippi, Y., Naylies, C., Bertrand-Michel, J., Belgnaoui, A.A., Theodorou, V., Marchi, N., Gourdy, P., Gamet-Payrastre, L., Loiseau, N., Guillou, H., Mselli-Lakhal, L., 2019. Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor. Sci Rep 9, 20169.

Rivière, G., Jean, J., Gorecki, S., Hulin, M., Kolf-Clauw, M., Feidt, C., Picard-Hagen, N., Vasseur, P., Le Bizec, B., Sirot, V., 2019. Dietary exposure to perfluoroalkyl acids, brominated flame retardants and health risk assessment in the French infant total diet study. Food Chem Toxicol 131, 110561.

Serra, H., Beausoleil, C., Habert, R., Minier, C., Picard-Hagen, N., Michel, C., 2019. Evidence for Bisphenol B Endocrine Properties: Scientific and Regulatory Perspectives. Environ Health Perspect 127, 106001.



Beausoleil, C., Emond, C., Cravedi, J.-P., Antignac, J.-P., Applanat, M., Appenzeller, B.R., Beaudouin, R., Belzunces, L.P., Canivenc-Lavier, M.-C., Chevalier, N., Chevrier, C., Elefant, E., Eustache, F., Habert, R., Kolf-Clauw, M., Le Magueresse-Battistoni, B., Mhaouty-Kodja, S., Minier, C., Multigner, L., Schroeder, H., Thonneau, P., Viguié, C., Pouzaud, F., Ormsby, J.-N., Rousselle, C., Verines-Jouin, L., Pasquier, E., Michel, C., 2018. Regulatory identification of BPA as an endocrine disruptor: Context and methodology. Mol Cell Endocrinol 475, 4–9.

Grandin, F.C., Gayrard, V., Lacroix, M.Z., Picard-Hagen, N., Mila, H., Toutain, P.-L., 2018a. Comment on “Pharmacokinetics of bisphenol S in humans after a single oral administration.” Environ Int 116, 29.

Grandin, F.C., Lacroix, M.Z., Gayrard, V., Gauderat, G., Mila, H., Toutain, P.-L., Picard-Hagen, N., 2018b. Bisphenol S instead of Bisphenol A: Toxicokinetic investigations in the ovine materno-feto-placental unit. Environ Int 120, 584–592.

Robles, M., Dubois, C., Gautier, C., Dahirel, M., Guenon, I., Bouraima-Lelong, H., Viguié, C., Wimel, L., Couturier-Tarrade, A., Chavatte-Palmer, P., 2018a. Maternal parity affects placental development, growth and metabolism of foals until 1 year and a half. Theriogenology 108, 321–330.

Robles, M., Nouveau, E., Gautier, C., Mendoza, L., Dubois, C., Dahirel, M., Lagofun, B., Aubrière, M.-C., Lejeune, J.-P., Caudron, I., Guenon, I., Viguié, C., Wimel, L., Bouraima-Lelong, H., Serteyn, D., Couturier-Tarrade, A., Chavatte-Palmer, P., 2018b. Maternal obesity increases insulin resistance, low-grade inflammation and osteochondrosis lesions in foals and yearlings until 18 months of age. PLoS One 13, e0190309.

Viguié, C., Mhaouty-Kodja, S., Habert, R., Chevrier, C., Michel, C., Pasquier, E., 2018. Evidence-based adverse outcome pathway approach for the identification of BPA as en endocrine disruptor in relation to its effect on the estrous cycle. Mol Cell Endocrinol 475, 10–28.



Gauderat, G., Picard-Hagen, N., Toutain, P.-L., Servien, R., Viguié, C., Puel, S., Lacroix, M.Z., Corbel, T., Bousquet-Melou, A., Gayrard, V., 2017. Prediction of human prenatal exposure to bisphenol A and bisphenol A glucuronide from an ovine semi-physiological toxicokinetic model. Sci Rep 7, 15330.

Grandin, F., Picard-Hagen, N., Gayrard, V., Puel, S., Viguié, C., Toutain, P.-L., Debrauwer, L., Lacroix, M.Z., 2017. Development of an on-line solid phase extraction ultra-high-performance liquid chromatography technique coupled to tandem mass spectrometry for quantification of bisphenol S and bisphenol S glucuronide: Applicability to toxicokinetic investigations. J Chromatogr A 1526, 39–46.

Guignard, D., Gayrard, V., Lacroix, M.Z., Puel, S., Picard-Hagen, N., Viguié, C., 2017. Evidence for bisphenol A-induced disruption of maternal thyroid homeostasis in the pregnant ewe at low level representative of human exposure. Chemosphere 182, 458–467.

Vabre, P., Gatimel, N., Moreau, J., Gayrard, V., Picard-Hagen, N., Parinaud, J., Leandri, R.D., 2017. Environmental pollutants, a possible etiology for premature ovarian insufficiency: a narrative review of animal and human data. Environ Health 16, 37.



Esteban-Gil, A., Jacquiet, P., Florentin, S., Decaudin, A., Berthelot, X., Ronsin, P., Grisez, C., Prevot, F., Alzieu, J.P., Marois, M., Corboz, N., Peglion, M., Vilardell, C., Liénard, E., Bouhsira, E., Castillo, J.A., Franc, M., Picard-Hagen, N., 2016. Does bovine besnoitiosis affect the sexual function of chronically infected bulls? Theriogenology 86, 1325–1332.

Gatimel, N., Lacroix, M.Z., Chanthavisouk, S., Picard-Hagen, N., Gayrard, V., Parinaud, J., Léandri, R.D., 2016. Bisphenol A in culture media and plastic consumables used for ART. Hum. Reprod. 31, 1436–1444.

Gauderat, G., Picard-Hagen, N., Toutain, P.-L., Corbel, T., Viguié, C., Puel, S., Lacroix, M.Z., Mindeguia, P., Bousquet-Melou, A., Gayrard, V., 2016. Bisphenol A glucuronide deconjugation is a determining factor of fetal exposure to bisphenol A. Environ Int 86, 52–59.

Guignard, D., Gauderat, G., Gayrard, V., Lacroix, M.Z., Picard-Hagen, N., Puel, S., Toutain, P.-L., Viguié, C., 2016. Characterization of the contribution of buccal absorption to internal exposure to bisphenol A through the diet. Food Chem. Toxicol. 93, 82–88.



Collet, S.H., Picard-Hagen, N., Lacroix, M.Z., Puel, S., Viguié, C., Bousquet-Melou, A., Toutain, P.-L., Gayrard, V., 2015. Allometric scaling for predicting human clearance of bisphenol A. Toxicol. Appl. Pharmacol. 284, 323–329.

Corbel, T., Perdu, E., Gayrard, V., Puel, S., Lacroix, M.Z., Viguié, C., Toutain, P.-L., Zalko, D., Picard-Hagen, N., 2015. Conjugation and deconjugation reactions within the fetoplacental compartment in a sheep model: a key factor determining bisphenol A fetal exposure. Drug Metab. Dispos. 43, 467–476.

Gayrard, V., Gauderat, G., Lacroix, M.Z., Viguié, C., Bousquet-Melou, A., Toutain, P.-L., Picard-Hagen, N., 2015. Comment on “In Vitro Effects of Bisphenol A β-D-Glucuronide (BPA-G) on Adipogenesis in Human and Murine Preadipocytes.” Environ. Health Perspect. 123, A289.

Picard-Hagen, N., Berthelot, X., Champion, J.L., Eon, L., Lyazrhi, F., Marois, M., Peglion, M., Schuster, A., Trouche, C., Garin-Bastuji, B., 2015. Contagious epididymitis due to Brucella ovis: relationship between sexual function, serology and bacterial shedding in semen. BMC Vet Res 11, 125.

Picard-Hagen, N., Lhermie, G., Florentin, S., Merle, D., Frein, P., Gayrard, V., 2015. Effect of gonadorelin, lecirelin, and buserelin on LH surge, ovulation, and progesterone in cattle. Theriogenology 84, 177–183.



Bemrah, N., Jean, J., Rivière, G., Sanaa, M., Leconte, S., Bachelot, M., Deceuninck, Y., Bizec, B.L., Dauchy, X., Roudot, A.-C., Camel, V., Grob, K., Feidt, C., Picard-Hagen, N., Badot, P.-M., Foures, F., Leblanc, J.-C., 2014. Assessment of dietary exposure to bisphenol A in the French population with a special focus on risk characterisation for pregnant French women. Food Chem Toxicol 72, 90–97.

Corbel, T., Gayrard, V., Puel, S., Lacroix, M.Z., Berrebi, A., Gil, S., Viguié, C., Toutain, P.-L., Picard-Hagen, N., 2014. Bidirectional placental transfer of Bisphenol A and its main metabolite, Bisphenol A-Glucuronide, in the isolated perfused human placenta. Reprod. Toxicol. 47, 51–58.

Esteban-Gil, A., Grisez, C., Prevot, F., Florentin, S., Decaudin, A., Picard-Hagen, N., Berthelot, X., Ronsin, P., Alzieu, J.P., Marois, M., Corboz, N., Peglion, M., Vilardell, C., Liénard, E., Bouhsira, E., Castillo, J.A., Franc, M., Jacquiet, P., 2014. No detection of Besnoitia besnoiti DNA in the semen of chronically infected bulls. Parasitol Res 113, 2355–2362.

Simões, V.G., Lyazrhi, F., Picard-Hagen, N., Gayrard, V., Martineau, G.-P., Waret-Szkuta, A., 2014. Variations in the vulvar temperature of sows during proestrus and estrus as determined by infrared thermography and its relation to ovulation. Theriogenology 82, 1080–1085.



Corbel, T., Gayrard, V., Viguié, C., Puel, S., Lacroix, M.Z., Toutain, P.-L., Picard-Hagen, N., 2013. Bisphenol A disposition in the sheep maternal-placental-fetal unit: mechanisms determining fetal internal exposure. Biol. Reprod. 89, 11.

Gayrard, V., Lacroix, M.Z., Collet, S.H., Viguié, C., Bousquet-Melou, A., Toutain, P.-L., Picard-Hagen, N., 2013a. High bioavailability of bisphenol A from sublingual exposure. Environ Health Perspect 121, 951–956.

Gayrard, V., Lacroix, M.Z., Collet, S.H., Viguié, C., Bousquet-Melou, A., Toutain, P.-L., Picard-Hagen, N., 2013b. Interpreting bisphenol a absorption in the canine oral cavity: Gayrard et al. Respond. Environ. Health Perspect. 121, A323-324.

Regnier, A., Laroute, V., Gautier-Bouchardon, A., Gayrard, V., Picard-Hagen, N., Toutain, P.-L., 2013. Florfenicol concentrations in ovine tear fluid following intramuscular and subcutaneous administration and comparison with the minimum inhibitory concentrations against mycoplasmal strains potentially involved in infectious keratoconjunctivitis. Am. J. Vet. Res. 74, 268–274.

Viguié, C., Collet, S.H., Gayrard, V., Picard-Hagen, N., Puel, S., Roques, B.B., Toutain, P.-L., Lacroix, M.Z., 2013. Maternal and fetal exposure to bisphenol a is associated with alterations of thyroid function in pregnant ewes and their newborn lambs. Endocrinology 154, 521–528.



Meyer, G., Deplanche, M., Roux, D., Moulignie, M., Picard-Hagen, N., Lyazrhi, F., Raboisson, D., Mathevet, P., Schelcher, F., 2012. Fetal protection against bovine viral diarrhoea type 1 virus infection after one administration of a live-attenuated vaccine. Vet J 192, 242–245.

Roques, B.B., Lacroix, M.Z., Puel, S., Gayrard, V., Picard-Hagen, N., Jouanin, I., Perdu, E., Martin, P.G., Viguié, C., 2012. CYP450-dependent biotransformation of the insecticide fipronil into fipronil sulfone can mediate fipronil-induced thyroid disruption in rats. Toxicol Sci 127, 29–41.



Gayrard, V., Picard-Hagen, N., Viguié, C., Toutain, P.-L., 2011. Competitive binding to plasma thyroid hormone transport proteins and thyroid disruption by phenylbutazone used as a probe. Gen Comp Endocrinol 174, 225–231.

Lacroix, M.Z., Puel, S., Collet, S.H., Corbel, T., Picard-Hagen, N., Toutain, P.L., Viguié, C., Gayrard, V., 2011. Simultaneous quantification of bisphenol A and its glucuronide metabolite (BPA-G) in plasma and urine: applicability to toxicokinetic investigations. Talanta 85, 2053–2059.



Collet, S.H., Picard-Hagen, N., Viguié, C., Lacroix, M.Z., Toutain, P.-L., Gayrard, V., 2010. Estrogenicity of bisphenol a: a concentration-effect relationship on luteinizing hormone secretion in a sensitive model of prepubertal lamb. Toxicol. Sci. 117, 54–62.

Leghait, J., Gayrard, V., Toutain, P.-L., Picard-Hagen, N., Viguié, C., 2010. Is the mechanisms of fipronil-induced thyroid disruption specific of the rat: Re-evaluation of fipronil thyroid toxicity in sheep? Toxicol Lett 194, 51–57.



Leghait, J., Gayrard, V., Picard-Hagen, N., Camp, M., Perdu, E., Toutain, P.-L., Viguié, C., 2009. Fipronil-induced disruption of thyroid function in rats is mediated by increased total and free thyroxine clearances concomitantly to increased activity of hepatic enzymes. Toxicology 255, 38–44.

Viguié, C., Picard-Hagen, N., Gayrard, V., Toutain, P.-L., 2009. Increased GH secretion in scrapie, a prion-associated neurodegenerative disease, is not due to suppressed IGF-1 negative feedback. Domest Anim Endocrinol 36, 127–137.



Gayrard, V., Picard-Hagen, N., Viguié, C., Jeunesse, E., Tabouret, G., Rezaei, H., Toutain, P.-L., 2008. Blood clearance of the prion protein introduced by intravenous route in sheep is influenced by host genetic and physiopathologic factors. Transfusion 48, 609–619.



Bousquet-Mélou, A., Formentini, E., Picard-Hagen, N., Delage, L., Laroute, V., Toutain, P.-L., 2006. The adrenocorticotropin stimulation test: contribution of a physiologically based model developed in horse for its interpretation in different pathophysiological situations encountered in man. Endocrinology 147, 4281–4291.

Picard-Hagen, N., Gayrard, V., Viguié, C., Moudjou, M., Imbs, C., Toutain, P.-L., 2006. Prion protein in the cerebrospinal fluid of healthy and naturally scrapie-affected sheep. J Gen Virol 87, 3723–3727.



Gayrard, V., Picard-Hagen, N., Viguié, C., Laroute, V., Andréoletti, O., Toutain, P.-L., 2005. A possible pharmacological explanation for quinacrine failure to treat prion diseases: pharmacokinetic investigations in a ovine model of scrapie. Br J Pharmacol 144, 386–393.


Véronique GAYRARD
Phone +33 561 19 39 18

Modification date : 08 June 2023 | Publication date : 15 July 2010 | Redactor : VG