Our publications

2024

Gut microbiota drives colon cancer risk associated with diet: a comparative analysis of meat-based and pesco-vegetarian diets. De Filippo C, Chioccioli S, Meriggi N, Troise AD, Vitali F, Mejia Monroy M, Özsezen S, Tortora K, Balvay A, Maudet C, Naud N, Fouché E, Buisson C, Dupuy J, Bézirard V, Chevolleau S, Tondereau V, Theodorou V, Maslo C, Aubry P, Etienne C, Giovannelli L, Longo V, Scaloni A, Cavalieri D, Bouwman J, Pierre F, Gérard P, Guéraud F, Caderni G. Microbiome. 2024 ;12(1):180.

Translational evaluation of Gelsectan® effects on gut barrier dysfunction and visceral pain in animal models and irritable bowel syndrome with diarrhoea.  Inczefi O, Eutamene H, Placide F, Tondereau V, Pallagi P, Bagyánszki M, Bódi N, Gémes N, Szebeni G, Molnár T, Theodorou V, Róka R. United European Gastroenterol J. 2024;12(8):1102-1113

Calcium-rich dairy matrix protects better than mineral calcium against colonic luminal haem-induced alterations in rats. Olier M, Naud N, Fouché E, Tondereau V, Ahn I, Leconte N, Blas-Y-Estrada Fe, Garric G, Heliès-Toussaint C, Harel-Oger M, Marmonier C, Théodorou V, Guéraud F, Jan Gl, Pierre F. (2024) Npj Science of Food. 8(1):43.doi: 10.1038/s41538-024-00273-y. PMID: 38956092; PMCID: PMC11220098. 

When subcellular chemical imaging enlightens our understanding on intestinal absorption, intracellular fate and toxicity of PFOA in vitro. Stoffels CBA, Cambier S, Subirana MA, Schaumlöffel D, Gomez G, Pittois D, Guignard C, Schwamborn JC, Wirtz T, Gutleb AC, Mercier-Bonin M, Audinot JN. J Hazard Mater. 2024 Oct 18;480:136205. doi: 10.1016/j.jhazmat.2024.136205. PMID: 39454333.

Effect of diet supplemented with functional amino acids and polyphenols on gut health in broilers subjected to a corticosterone-induced stress. Yvon S, Beaumont M, Dayonnet A, Eutamène H, Lambert W, Tondereau V, Chalvon-Demersay T, Belloir P, Paës C. Sci Rep. 2024 Jan 10;14(1):1032. doi: 10.1038/s41598-023-50852-4. PMID: 38200093

2023

• Traditional fermented milk products of Eastern Mediterranean countries: A cultural heritage to preserve.Reine AbiKhalil*, Sophie Yvon*, Christel Couderc, Gwenaelle Jard, Rabih El Rammouz, Pierre Abi Nakhoul, Hélène Eutamène, Marie-José Ayoub, Hélène Tormo. August 2023 International Dairy Journal DOI :10.1016/j.idairyj.2023.105768
• Microbial Dynamics during labneh Ambaris Production in Earthenware Jars. Abi Khalil R, Couderc C, Yvon S, Sicard D, Bigey F, Jard G, El Rammouz R, Abi Nakhoul P, Eutamène H, Ayoub MJ, Tormo H. 2023 Aug 21;12(16):3131. doi: 10.3390/foods12163131. PMID: 37628130; PMCID: PMC10453334.
• Urinary Metabolome Analysis Reveals Potential Microbiota Alteration and Electrophilic Burden Induced by High Red Meat Diet: Results from the French NutriNet-Santé Cohort and an In Vivo Intervention Study in Rats. Mervant L, Tremblay-Franco M, Olier M, Jamin E, Martin JF, Trouilh L, Buisson C, Naud N, Maslo C, Héliès-Toussaint C, Fouché E, Kesse-Guyot E, Hercberg S, Galan P, Deschasaux-Tanguy M, Touvier M, Pierre F, Debrauwer L, Guéraud F. Mol Nutr Food Res. 2023 Mar;67(5):e2200432. doi: 10.1002/mnfr.202200432. Epub 2023 Feb 2. PMID: 36647294.
• Microbial communities and main features of labneh Ambaris, a traditional Lebanese fermented goat milk product. Abi Khalil R, Yvon S, Couderc C, Belahcen L, Jard G, Sicard D, Bigey F, El Rammouz R, Abi Nakhoul P, Eutamène H, Tormo H, Ayoub MJ. J Dairy Sci. 2023 Feb;106(2):868-883. doi: 10.3168/jds.2022-22275. Epub 2022 Dec 19. PMID: 36543637.
• Fate, uptake and gut toxicity of two colloidal silver products in mice: how micro X-ray fluorescence, micro X-ray absorption spectroscopy and near-infrared spectroscopy provide new insights in food nanotoxicology. Gillois, K., Rivard, C., Levasseur-Garcia, C., Bezirard, V., Terrisse, H., Leonard, R., ... & Robert, H. (2023).  Environmental Science: Nano, 10(3), 902-921.
• Microplastics: What happens in the human digestive tract? First evidences in adults using in vitro gut models. Fournier E, Leveque M, Ruiz P, Ratel J, Durif C, Chalancon S, Amiard F, Edely M, Bezirard V, Gaultier E, Lamas B, Houdeau E, Lagarde F, Engel E, Etienne-Mesmin L, Blanquet-Diot S, Mercier-Bonin M. J Hazard Mater. 2023 Jan 15;442:130010. doi: 10.1016/j.jhazmat.2022.130010. Epub 2022 Sep 21. PMID: 36182891.
• Profiling of PFOA-Exposed Mouse Liver by Multi-Modal Mass Spectrometry Analysis. Stoffels CBA, Angerer TB, Robert H, Poupin N, Lakhal L, Frache G, Mercier-Bonin M, Audinot JN. Lipidomic Anal Chem. 2023 Apr 7. doi: 10.1021/acs.analchem.2c05470. Epub ahead of print. PMID: 37027489
• O-Mucin-degrading carbohydrate-active enzymes and their possible implication in inflammatory bowel diseases. Labourel A, Parrou JL, Deraison C, Mercier-Bonin M, Lajus S, Potocki-Veronese G.  Essays Biochem. 2023 Apr 18;67(3):331-344. doi: 10.1042/EBC20220153. PMID: 36912232.

2022

• Maternal heme-enriched diet promotes a gut pro-oxidative status associated with microbiota alteration, gut leakiness and glucose intolerance in mice offspring. Mazenc A, Mervant L, Maslo C, Lencina C, Bézirard V, Levêque M, Ahn I, Alquier-Bacquié V, Naud N, Héliès-Toussaint C, Debrauwer L, Chevolleau S, Guéraud F, Pierre FHF, Théodorou V, Olier M. Redox Biol. 2022 Jul;53:102333. doi: 10.1016/j.redox.2022.102333. Epub 2022 May 12. PMID: 35588638; PMCID: PMC9119830
• Human milk oligosaccharides alleviate stress-induced visceral hypersensitivity and associated microbiota dysbiosis. Ferrier L, Eutamène H, Siegwald L, Marquard AM, Tondereau V, Chevalier J, Jacot GE, Favre L, Theodorou V, Vicario M, Rytz A, Bergonzelli G, Garcia-Rodenas CL. J Nutr Biochem. 2022 Jan;99:108865. doi: 10.1016/j.jnutbio.2021.108865. Epub 2021 Sep 25. PMID: 34582967.
• In vitro models of gut digestion across childhood: current developments, challenges and future trends. Fournier E, Roussel C, Dominicis A, Ley D, Peyron MA, Collado V, Mercier-Bonin M, Lacroix C, Alric M, Van de Wiele T, Chassard C, Etienne-Mesmin L, Blanquet-Diot S. Biotechnol Adv. 2022 Jan-Feb;54:107796. doi: 10.1016/j.biotechadv.2021.107796. Epub 2021 Jul 9. PMID:34252564.
• Exposure to polyethylene microplastics alters immature gut microbiome in an infant in vitro gut model. Fournier E, Ratel J, Denis S, Leveque M, Ruiz P, Mazal C, Amiard F, Edely M, Bezirard V, Gaultier E, Lamas B, Houdeau E, Engel E, Lagarde F, Etienne-Mesmin L, Mercier-Bonin M, Blanquet-Diot S. J Hazard Mater. 2023 Feb 5;443(Pt B):130383. doi: 10.1016/j.jhazmat.2022.130383. Epub 2022 Nov 11. PMID: 36444070.
• A child is not an adult: development of a new in vitro model of the toddler colon. Fournier E, Denis S, Dominicis A, Van de Wiele T, Alric M, Mercier-Bonin M, Etienne-Mesmin L, Blanquet-Diot S. Appl Microbiol Biotechnol. 2022 Nov;106(21):7315-7336. doi: 10.1007/s00253-022-12199-0. Epub 2022 Oct 7. PMID: 36202936.
• Lactococcus lactis NCDO2118 exerts visceral antinociceptive properties in rat via GABA production in the gastro-intestinal tract. Laroute V, Beaufrand C, Gomes P, Nouaille S, Tondereau V, Daveran-Mingot ML, Theodorou V, Eutamene H, Mercier-Bonin M, Cocaign-Bousquet M. Elife. 2022 Jun 21;11:e77100. doi: 10.7554/eLife.77100. PMID: 35727704; PMCID: PMC9213000.
• Artisanal Household Milk Pasteurization Is Not a Determining Factor in Structuring the Microbial Communities of Labneh Ambaris: A Pilot Study. Abi Khalil R, Couderc C, Yvon S, Jard G, Sicard D, Bigey F, El Rammouz R, Abi Nakhoul P, Eutamène H, Tormo H, Ayoub MJ. Foods. 2022 Dec 1;11(23):3S874.doi: 10.3390/foods11233874. PMID: 36496682; PMCID: PMC9740543.

2021

• Bisphenol A, S or F mother's dermal impregnation impairs offspring immune responses in a dose and sex-specific manner in mice. Malaisé Y, Lencina C, Cartier C, Olier M, Ménard S, Guzylack-Piriou L. Sci Rep. 2021 Jan 18;11(1):1650. doi: 10.1038/s41598-021-81231-6. PMID: 33462300; PMCID: PMC7813853.
• Microplastics in the human digestive environment: A focus on the potential and challenges facing in vitro gut model development. Fournier E, Etienne-Mesmin L, Grootaert C, Jelsbak L, Syberg K, Blanquet-Diot S, Mercier-Bonin M. J Hazard Mater. 2021 Aug 5;415:125632. doi: 10.1016/j.jhazmat.2021.125632.  Epub 2021 Mar 11. PMID: 33770682.
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• Repeated exposure of Caco-2 versus Caco-2/HT29-MTX intestinal cell models to (nano)silver in vitro: Comparison of two commercially available colloidal silver products. Gillois K, Stoffels C, Leveque M, Fourquaux I, Blesson J, Mils V, Cambier S, Vignard J, Terrisse H, Mirey G, Audinot JN, Theodorou V, Ropers MH, Robert H, Mercier-Bonin M.  Sci Total Environ. 2021 Feb 1;754:142324. doi: 10.1016/j.scitotenv.2020.142324. Epub 2020 Sep 17. PMID: 33254900.
• In vitro digestion of food grade TiO2 (E171) and TiO2 nanoparticles: physicochemical characterization and impact on the activity of digestive enzymes. Dudefoi W, Rabesona H, Rivard C, Mercier-Bonin M, Humbert B, Terrisse H, Ropers MH. Food Funct. 2021 Jul 5;12(13):5975-5988. doi: 10.1039/d1fo00499a. PMID: 34032251.
• Revisiting definition and assessment of intestinal trans-epithelial passage. Ilchmann-Diounou H, Buleon M, Bacquie V, Theodorou V, Denis C, Menard S. Cell Mol Life Sci. 2021 Dec;78(24):8157-8164. doi: 10.1007/s00018-021-04000-8. Epub 2021 Nov 3. PMID: 34731253; PMCID: PMC8629865.
• The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice. Barretto SA, Lasserre F, Huillet M, Régnier M, Polizzi A, Lippi Y, Fougerat A, Person E, Bruel S, Bétoulières C, Naylies C, Lukowicz C, Smati S, Guzylack L, Olier M, Théodorou V, Mselli-Lakhal L, Zalko D, Wahli W, Loiseau N, Gamet- Payrastre L, Guillou H, Ellero-Simatos S. Microbiome. 2021 Apr 20;9(1):93. doi: 10.1186/s40168-021-01050-9. PMID: 33879258; PMCID: PMC8059225.

2020

• Inczefi O, Bacquié V, Olier-Pierre M, Rincel M, Ringot-Destrez B, Ellero- Simatos S, Eutamène H, Bétoulières C, Thomas J, Lainé J, Gros L, Lévêque M, Leonard R, Harkat C, Robbe-Masselot C, Róka R, Mercier-Bonin M, Theodorou V, Darnaudéry M, Turner JR, Ferrier L. Targeted Intestinal Tight Junction Hyperpermeability Alters the Microbiome, Behavior, and Visceromotor Responses. Cell Mol Gastroenterol Hepatol. 2020;10(1):206-208.e3. doi: 10.1016/j.jcmgh.2020.02.008. Epub 2020 Mar 6. PMID: 32147490; PMCID: PMC7296230.
• Bi Y, Marcus AK, Robert H, Krajmalnik-Brown R, Rittmann BE, Westerhoff P, Ropers MH, Mercier-Bonin M. The complex puzzle of dietary silver nanoparticles, mucus and microbiota in the gut. J Toxicol Environ Health B Crit Rev. 2020;23(2):69-89. doi: 10.1080/10937404.2019.1710914. Epub 2020 Jan 10. PMID: 31920169.
• Martín R, Bottacini F, Egan M, Chamignon C, Tondereau V, Moriez R, Knol J,Langella P, Eutamene H, Smokvina T, van Sinderen D. The Infant-Derived<i>Bifidobacterium bifidum</i> Strain CNCM I-4319 Strengthens Gut Functionality.Microorganisms. 2020 Aug 28;8(9):1313.doi:10.3390/microorganisms8091313. PMID:32872165; PMCID: PMC7565306.
• Theodorou V,Beaufrand C, Yvon S, Laforge G, Burmeister Y, Müller A, Seilheimer B, Bueno L, Eutamene H. The multicomponent medication Spascupreel attenuates stress-induced gut dysfunction in rats. Neurogastroenterol Motil. 2020 May;32(5):e13798. doi: 10.1111/nmo.13798. Epub 2020 Feb 14. PMID: 32059072; PMCID: PMC7217055.
• Beaumont M, Paës C, Mussard E, Knudsen C, Cauquil L, Aymard P, Barilly C, Gabinaud B, Zemb O, Fourre S, Gautier R, Lencina C, Eutamène H,Theodorou V, Canlet C, Combes S. Gut microbiota derived metabolites contribute to intestinal barrier maturation at the suckling-to-weaning transition. Gut Microbes. 2020 Sep 2;11(5):1268-1286. doi: 10.1080/19490976.2020.1747335. Epub 2020 Apr 30. PMID: 32352849; PMCID: PMC7524271.
• Kamphuis JBJ, Guiard B, Leveque M, Olier M, Jouanin I, Yvon S, Tondereau V, Rivière P, Guéraud F, Chevolleau S, Noguer-Meireles MH, Martin JF, Debrauwer L, Eutamène H, Theodorou V. Lactose and Fructo-oligosaccharides Increase Visceral Sensitivity in Mice via Glycation Processes, Increasing Mast Cell Density in Colonic Mucosa. Gastroenterology. 2020 Feb;158(3):652-663.e6. doi: 10.1053/j.gastro.2019.10.037. Epub 2019 Nov 9. PMID: 31711923.
• Payros D, Ménard S, Laffitte J, Neves M, Tremblay-Franco M, Luo S, Fouche E, Snini SP, Theodorou V, Pinton P, Oswald IP. The food contaminant, deoxynivalenol, modulates the Thelper/Treg balance and increases inflammatory bowel diseases. Arch Toxicol. 2020 Sep;94(9):3173-3184. doi: 10.1007/s00204-020-02817-z. Epub 2020 Jul 2. PMID: 32617661.
• Keller J, Chevolleau S, Noguer-Meireles MH, Pujos-Guillot E, Delosière M, Chantelauze C, Joly C, Blas-Y-Estrada F, Jouanin I, Durand D, Pierre F, Debrauwer L, Theodorou V, Guéraud F. Heme-Iron-Induced Production of 4-Hydroxynonenal in Intestinal Lumen May Have Extra-Intestinal Consequences through Protein-Adduct Formation. Antioxidants (Basel). 2020 Dec 17;9(12):1293. doi: 10.3390/antiox9121293. PMID: 33348697; PMCID: PMC7766870.
• Coméra C, Cartier C, Gaultier E, Catrice O, Panouille Q, El Hamdi S, Tirez K, Nelissen I, Théodorou V, Houdeau E. Jejunal villus absorption and paracellular tight junction permeability are major routes for early intestinal uptake of food-grade TiO₂ particles: an in vivo and ex vivo study in mice. Part Fibre Toxicol. 2020 Jun 11;17(1):26. doi: 10.1186/s12989-020-00357-z. PMID: 32527323; PMCID: PMC7345522.
• Malaisé Y, Lencina C, Placide F, Bacquié V, Cartier C, Olier M, Buettner M, Wallbrecht M, Ménard S, Guzylack-Piriou L. Oral exposure to bisphenols induced food intolerance and colitis in vivo by modulating immune response in adult mice. Food Chem Toxicol. 2020 Dec;146:111773. doi: 10.1016/j.fct.2020.111773. Epub 2020 Oct 1. PMID: 33011352.
• Malaisé Y, Lencina C, Cartier C, Olier M, Ménard S, Guzylack-Piriou L. Perinatal oral exposure to low doses of bisphenol A, S or F impairs immune functions at intestinal and systemic levels in female offspring mice. Environ Health. 2020 Aug 31;19(1):93. doi: 10.1186/s12940-020-00614-w. PMID: 32867778;PMCID: PMC7457519.

2019

• Kamphuis JBJ, Guiard B, Leveque M, Olier M, Jouanin I, Yvon S, Tondereau V, Rivière P, Guéraud F, Chevolleau S, Noguer-Meireles MH, Martin JF, Debrauwer L, Eutamène H, Theodorou V. Lactose and Fructo-oligosaccharides Increase Visceral Sensitivity in Mice via Glycation Processes, Increasing Mast Cell Density in Colonic Mucosa. Gastroenterology. 2019 Nov 8. pii: S0016-5085(19)41528-X. doi: 10.1053/j.gastro.2019.10.037.
• Ilchmann-Diounou H, Olier M, Lencina C, Riba A, Barretto S, Nankap M, Sommer C, Guillou H, Ellero-Simatos S, Guzylack-Piriou L, Théodorou V, Ménard S. Early life stress induces type 2 diabetes-like features in ageing mice. Brain Behav Immun. 2019 Aug;80:452-463. doi: 10.1016/j.bbi.2019.04.025.
• Martin OCB, Olier M, Ellero-Simatos S, Naud N, Dupuy J, Huc L, Taché S, Graillot V, Levêque M, Bézirard V, Héliès-Toussaint C, Estrada FBY, Tondereau V,  Lippi Y, Naylies C, Peyriga L, Canlet C, Davila AM, Blachier F, Ferrier L, Boutet-Robinet E, Guéraud F, Théodorou V, Pierre FHF. Haem iron reshapes colonic luminal environment: impact on mucosal homeostasis and microbiome through aldehyde formation. Microbiome. 2019 May 6;7(1):72. doi:10.1186/s40168-019-0685-7.
• Rincel M, Olier M, Minni A, de Oliveira CM, Matime Y, Gaultier E, Grit I, Helbling JC, Costa AM, Lépinay A, Moisan MP, Layé S, Ferrier L, Parnet P, Theodorou V, Darnaudéry M. Pharmacological restoration of gut barrier function in stressed neonates partially reverses long-term alterations associated with maternal separation. Psychopharmacology (Berl). 2019 May;236(5):1583-1596. doi: 10.1007/s00213-019-05252-w.
• Yvon S, Schwebel L, Belahcen L, Tormo H, Peter M, Haimoud-Lekhal DA, Eutamene H, Jard G. Effects of thermized donkey milk with lysozyme activity on altered gut barrier in mice exposed to water-avoidance stress. J Dairy Sci. 2019 Sep;102(9):7697-7706. doi: 10.3168/jds.2019-16642.
• Maes E, Sadovskaya I, Lévêque M, Elass-Rochard E, Payré B, Grard T, Théodorou V, Guérardel Y, Mercier-Bonin M. Structure and biological activities of a hexosamine-rich cell wall polysaccharide isolated from the probiotic Lactobacillus farciminis. Glycoconj J. 2019 Feb;36(1):39-55. doi:10.1007/s10719-018-09854-y.
• Sundin J, Nordlander S, Eutamene H, Alquier-Bacquie V, Cartier C, Theodorou V, Le Nevé B, Törnblom H, Simrén M, Öhman L. Colonic mast cell numbers, symptom profile, and mucosal expression of elements of the epithelial barrier in irritable bowel syndrome. Neurogastroenterol Motil. 2019 Sep 13:e13701. doi:10.1111/nmo.13701.