Portraits - ACCUEIL

PIERRE Fabrice

Co- leader of the PPCF team

DR1/INRAE [Ph.D., HDR]

Fabrice obtained his PhD in 1999 from the University of Nantes (INSERM U419, supervised by Dr Jean Memanteau). This doctoral project focused on the immunoprophylaxis of colorectal cancers by fermentable indigestible carbohydrates. After a year at the Institut Pasteur working on the virulence of Yersinia Pestis (Dr Elisabeth Carniel's team) and a year at the University of Burgundy working on the food bacterium Oenococcus oeni (formerly Leuconostoc oenos, Dr Jean Guzzo's team), he joined the PPCA team in 2002. He is currently co-leader of the team with Dr Françoise Guéraud, and a member of the Nutrition Activité physique Cancer Recherche (NACRe) network and the steering committees of the INRAE SYALSA (Food Systems & Health) and Biosefaire (Biodiversity and Ecosystem Services) metaprograms. His main areas of expertise concern the relationship between food, food additives, neo-formed products, food contaminants and colon cancer. In addition to work on the relationship between dietary fibers, red meats and deli meats and the initiation and promotion of carcinogenesis, he is developing interdisciplinary work integrating the food system and benefit-risk analyses in food toxicology.

fabrice.pierre@inrae.fr

GUERAUD Francoise

Co- leader of the PPCF team

DR2 /INRAE [DVM, Ph.D., HDR]

Françoise is the co-leader with Fabrice Pierre of the PPCF team . She is a graduate of the Ecole Nationale Vétérinaire de Toulouse. After practicing veterinary medicine for a number of years, she completed her thesis on the effect of growth hormone on hepatic detoxification activities at the Xenobiotics Laboratory. Recruited by INRA in 1997, she then turned her attention to lipid oxidation products, first as biomarkers of oxidative stress, then to their presence in the diet and their involvement in the development of various diseases, notably colorectal cancer. With the AXIOM platform, she is developing targeted metabolomics approaches for toxicologically relevant compounds.

francoise.gueraud@inrae.fr

PLAISANCIE Pascale

DR2 /INRAE [Ph.D., HDR]

Pascale was recruited to INRA in 1996 (AlimH) to study colonic L enteroendocrine cells (UEPSD, Jouy en Josas). Her research has since led her to address the interactions between “Nutrients and protective factors of the intestinal mucosa” (Inserm U45, Normal and neoplastic intestinal epithelium, Lyon), then the role of environmental factors on the differentiation of intestinal epithelium (Inserm U865, Digestive endocrine tumors, Lyon). Between 2011 and 2019, she characterized the role of dietary lipids in intestinal barrier homeostasis (CarMeN laboratory, Cardiovascular Metabolism Endocrinology and Nutrition, Lyon). The common thread running through her projects is the search for nutritional strategies to compensate for intestinal barrier dysfunction. She has identified beta-casofensine, a new bioactive peptide with high health potential specifically targeting intestinal protection players (Patent EP2430044A1). In 2019, she joined TOXALIM's PPCA team to study the role of interactions between nutritional factors, colonic epithelium and mesenchymal cells in the initiation and progression of colorectal cancer.

pascale.plaisancie@inrae.fr

HELIES-TOUSSAINT Cécile

CRCN /INRAE [Ph.D.]

After working on fundamental research during her thesis (Laboratoire de Régulation des Gènes et Signalisation Cellulaire, INSERM) and her postdoctoral training (Laboratoire de Biologie Intégrée des Cellules Rénales, CNRS/CEA), Cécile turned to more applied research and joined INRA as a research fellow in 1998. She was recruited to the NASA (Nutrition, Food and Food Safety) department in the team headed by A. Grynberg (Membrane lipids and cardiovascular functions). In 2004, she took part in the formation of UMR 1154 (Lipid Nutrition and Functional Regulation of the Heart and Vessels). For 9 years she worked closely with A. Grynberg on the prevention of cardiovascular disease through diet. In September 2007 she joined the Unit 1089 Xenobiotics at Tolouse in the Biottox team. To stay within the field of diet-induced metabolic diseases and energy metabolism studies, while integrating the effects of xenobiotics, her research projects focused on the obesogenic effects of Bisphenol A and then its substitute Bisphenol S. In 2012, she joined the PPCF team. For the past 12 years, she has worked mainly on changes in energy metabolism during carcinogenesis. She is developing projects focusing on the prevention of human diseases through diet, using a dual approach: animal models and cellular models.

cecile.toussaint@inrae.fr

DUPUY Jacques

IR2 /INRAE [Ph.D.]

Recruited in 1991 as an engineer in the “Mycotoxicology” team (INRA UR66 laboratory), Jacques was responsible for the analytical development of mycotoxin assays and experiments on mold toxinogenesis (obtaining a PhD in 1994). In 1994, he joined the “Regulation of biotransformations and pharmacokinetics” team to work on the separation and purification of hepatic biotransformation enzymes (cytochromes P450) in livestock species. When the laboratory was reorganized in 1998, he joined the “Pharmacokinetics of antiparasitic drugs” team, studying the in vitro metabolism of endectocides via liver microsomes in target animal species and parasites. He studied the role of membrane transporters (P-glycoproteins) in the fate of endectocides via an in vitro approach (cell lines). In 2010, when the TOXALIM unit was set up, he decided to change direction and joined the “Prevention and promotion of colorectal carcinogenesis through diet” team, focusing on in vitro approaches = creation of murine colorectal epithelial cell lines depleted for key proteins in colorectal carcinogenesis (Apc, Nrf2), participation in the creation of a co-culture model combining murine colonic epithelial cells and murine colonic fibroblasts.

jacques.dupuy@inrae.fr

NAUD Nathalie

AI/INRAE

Coordinatrice Prévention-Garant ASAI

After working in a CNRS unit in Poitiers on fundamental research (photoreceptors), Nathalie joined INRA in 2005 in the Cancer and Food team of the Xenobiotics unit. In 2011, the unit became Toxalim and the team became PPCA. Nathalie manages animal studies to test the effects of food on models, and in particular on the colon. Nathalie also works on colonic and faecal samples from these experiments, carrying out biochemical analyses (TBARs, heme assays) and histological analyses (counting pre-neoplastic lesions: ACF and MDF; immunohistochemistry). Since joining INRA, Nathalie has also been involved in prevention: prevention assistant since 2006, unit coordinator since 2011, workplace first-aid attendant since 2006, ASAI guarantor since 2009, fire safety officer since 2010.

nathalie.naud.31@inrae.fr

BUISSON Charline

AI/INRAE

Charline joined INRAE in 2015 in the Carmen unit in Lyon. She worked on projects focusing mainly on understanding the mechanisms regulating lipemia and modulating postprandial hypertriglyceridemia and associated endotoxemia through nutritional strategies. She joined the PPCA team following a mobility in 2020. She works mainly on the management of the team's in vivo studies and on the analysis of associated samples (fecal and urinary biomarker assays, cytotoxicity tests, western blots, etc.).

charline.buisson@inrae.fr

FOUCHE Edwin

AI /INRAE

Edwin has worked in various ToxAlim teams since 2010 as an Assistant Engineer specializing in molecular biology techniques. In 2016, he joined the PPCA team, at the interface between in vivo and mechanistic studies on cellular models. He is mainly in charge of RNA transcript analysis and cytotoxicity studies on murine colonocytes.

edwin.fouche@inrae.fr

FOUSSET Occiane

TR/ CDD

After graduating with a degree in Cell Biology and Physiology, Occiane joined the CRCA (Centre de Recherche sur la Cognition Animale - Animal Cognition Research Center), working on behavioral studies in the mouse model. She then worked as a zootechnician at Physiogenex before joining the EZOP platform at Toxalim. Since September 2024, she has been working in the PPCA team, in charge of zootechnics and sample analysis (biomarker assays, cytotoxicity studies on murine cells).

occiane.fousset@inrae.fr

COGO Emma

Thèse_Ecole doc : SEVAB

Emma joined the PPCF team in 2021 for a 6-month internship. After obtaining her diploma (Ecole Nationale Supérieure Agronomique de Toulouse ENSAT), she decided to pursue her professional project in research, and is currently working on a thesis within the same team, supervised by Pascale Plaisancié and Françoise Guéraud: "Interest of the BMP signaling pathway in the prevention of colorectal cancer: study of a new nutritional strategy targeting the epithelial/mesenchymal dialogue".

emma.cogo@inrae.fr

OMOTOYINBO Adenike

Thèse_Ecole doc : SEVAB

Adenike is a native of Nigeria. She obtained her Master's degree in October 2023: Master of Science & Technology, Agrofood Chain option. She began her thesis in 2024: Viandes transformées, additifs nitrés et néoformations endogènes : impact de la baisse ou du retrait des additifs nitrés et toxicité comparées des alcénals et composés nitrosés under the joint supervision of Fabrice PIERRE and Françoise GUERAUD, at the SEVAB doctoral school - Sciences Ecologiques, Vétérinaires, Agronomiques et Bioingenieries.

adenike.omotoyinbo@inrae.fr

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