Nicolas, an organic chemist by training, did a thesis at CEA Saclay under the supervision of Pr M. Delaforge at the interface of Chemistry, Hepatic Metabolism and Molecular Modeling of interactions between contaminants and membrane proteins. He was recruited at INRA in 2002 as CR2 to study the fate of mycotoxins in livestock. In order to deepen his knowledge on sphingolipid metabolism, Nicolas chose to do a post-doctoral period in the Dermatology research unit of the VA Medical Center in San Francisco (Dr. Uchida Y. and Pr Holleran W. team) where he studied the sphingolipid composition of the Stratum Corneum and their implications in Gaucher's disease, Harlequin Ichthyosis and Atopic Dermatitis Upon his return from his post-doctoral studies, Nicolas joined the Integrative Toxicology and Metabolism team in order to develop toxicology projects integrating lipidomics and transcriptomics approaches. His current research project focuses on the impact of contaminants and environmental factors on hepatic metabolism.