Our research

Our research:

Characterization of genotoxic substances – In vitro approaches and development of genotoxicity assays

Context:

Digestive tract cells first, then those of other tissues after systemic passage, may be damaged by genotoxic agents, coming from food contaminants - for example from food contaminants. As a causal link has been established between DNA damage, mutagenesis and carcinogenesis, it is important to control exposure to genotoxic substances and monitor the resulting DNA damage.

Research:

We study and characterize genotoxic substances (pesticides, nanoparticles, genotoxins...). We are also interested in cellular effects, by analyzing cellular fates (persistence or repair of damage, cell cycle checkpoints, apoptosis, senescence, etc). Finally, we are involved in the development of genotoxicity tests, in order to monitor the effects of genotoxic substances in cells.

Issues:

The issues are to provide information on the potentially genotoxic effects of different food contaminants, alone or in mixtures, on different target tissues.

Work positioning:

In line with the INRAE and TOXALIM objectives, our research aim to provide answers to questions raised about genotoxic exposure and health effects, as well as tools to characterize genotoxic substances. Our work mainly contributes to the strategic axes defined by INRAE ​​Human Food and Animal Health departments: Improving human nutrition and consumers health; Develop research and produce generic data for life knowledge.

Fundings:

French National Agency for Research (ANR), La Ligue contre le cancer, INRAE - Human Alimentation and Animal Health departments, Occitany region. Thank you!