Seminar Emilien Jamin, le 7 février 2025

After obtaining a master's degree in mass spectrometry at Pierre & Marie Curie University under Professor Jean-Claude Tabet, Emilien completed his PhD on the mass spectrometry study of heterocyclic aromatic amines (AAHs) produced during meat cooking at INRAE in Toulouse.

During his thesis, he developed an original high-throughput analysis method using ionisation by metastable atoms, and studied the formation of covalent adducts to DNA by AAH metabolites through the structural characterisation of new adducts and preferentially modified DNA sequences.

After completing his PhD, he was immediately recruited by INRAE in 2007 to join the Toxalim unit, where he developed and applied original mass spectrometry methods to toxicology in order to identify known and unknown metabolites of xenobiotics, particularly reactive metabolites, identify and quantify unknown DNA adducts, and also to identify secondary fungal metabolites, particularly during Thaïs Hautbergue's thesis, which he co-supervised.

In 2010, I introduced untargeted metabolomics using mass spectrometry at the Metatoul platform, and in 2014, I pioneered the development of analytical approaches dedicated to the study of the internal chemical exposome.

All this work in analytical toxicology led to him obtaining his HDR (Habilitation à Diriger des Recherches, or accreditation to supervise research) in 2022. As co-leader of the AXIOM team since 2023, Emilien continues to develop this platform, which includes six mass spectrometers, one NMR spectrometer, eight permanent INRAE staff members and a dozen contract workers, focused on the development and application of mass spectrometry and NMR approaches for the analysis of metabolomes, xenobiotics and their metabolites, and exposomes in toxicology, human and animal health.

The AXIOM platform is a member of the Toulouse Metatoul metabolomics and fluxomics platform and the MetaboHUB national metabolomics infrastructure, for which Emilien is INRAE's representative within the France Exposome national infrastructure.