The AGE-RAGE axis in intestinal type 2 immunity

Jasper Kamphuis' Seminar, May 16, 2025. After preparing and obtaining his thesis in the NGN team on “Pathology, Toxicology, Genetics, and Nutrition” INP supervised by Vassilia Theodorou and Hélène Eutamène at Toxalim, Jasper completed a postdoctoral fellowship at INSERM at the Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy). In 2023, he was recruited as a CNRS researcher in the team led by Laurent Reber (INFINITy).

J Kamphuis 20250516

Jasper Kamphuis is currently Chargé de Recherche at the CNRS, based at the INFINITy laboratory in Toulouse. He performed his MSc thesis and internship with Bruno Sovran at Wageningen University, in his home country, the Netherlands. Bruno kindly introduced him to Vassilia Theodorou and Hélène Eutamène of the NGN team at Toxalim, and he performed a PhD thesis on the role of FODMAPs in visceral sensitivity and the gut mucus barrier here. He pursued postdoctoral research on anaphylaxis and mast cell biology. His current work focuses on the role of mucosal mast cells in intestinal inflammation and barrier dysfunction, with a particular interest in how dietary and microbial factors modulate immune responses in the gut. Jasper combines in vivo and ex vivo models, and immunological techniques to investigate host–diet–microbiota interactions. He’s excited to return to Toxalim and share recent developments from his work.

See also

jasper.kamphuis@inserm.fr

Croote D, Wong JJW, Pecalvel C, Leveque E, Casanovas N, Kamphuis JBJ, Creeks P, Romero J, Sohail S, Bedinger D, Nadeau KC, Chinthrajah RS, Reber LL, Lowman HB. J Allergy Clin Immunol. 2024 Jan;153(1):182-192.e7. doi: 10.1016/j.jaci.2023.08.035. Epub 2023 Sep 23. PMID: 37748654 Free PMC article.

Tauber M, Basso L, Martin J, Bostan L, Pinto MM, Thierry GR, Houmadi R, Serhan N, Loste A, Blériot C, Kamphuis JBJ, Grujic M, Kjellén L, Pejler G, Paul C, Dong X, Galli SJ, Reber LL, Ginhoux F, Bajenoff M, Gentek R, Gaudenzio N. J Exp Med. 2023 Oct 2;220(10):e20230570. doi: 10.1084/jem.20230570. Epub 2023 Jul 18. PMID: 37462672 Free PMC article.

Lamanna E, Conde E, Mougel A, Bonnefoy J, Colaone F, Godon O, Hamdi S, Kamphuis JBJ, Drouet B, Serra V, Bruhns P, Reber LL. Allergy. 2023 Jul;78(7):2028-2031. doi: 10.1111/all.15680. Epub 2023 Mar 1. PMID: 36799426 No abstract available.

Worrall WPM, Kamphuis JBJ, Stackowicz J, Mougel A, Mauré E, Pecalvel C, Brûlé S, Bruhns P, Guilleminault L, Reber LL. Allergy. 2022 Jun;77(6):1903-1906. doi: 10.1111/all.15269. Epub 2022 Mar 11. PMID: 35244223 No abstract available.

Conde E, Bertrand R, Balbino B, Bonnefoy J, Stackowicz J, Caillot N, Colaone F, Hamdi S, Houmadi R, Loste A, Kamphuis JBJ, Huetz F, Guilleminault L, Gaudenzio N, Mougel A, Hardy D, Snouwaert JN, Koller BH, Serra V, Bruhns P, Grouard-Vogel G, Reber LL. Nat Commun. 2021 May 11;12(1):2574. doi: 10.1038/s41467-021-22834-5. PMID: 33976140 Free PMC article.

Kamphuis JBJ, Worrall WPM, Stackowicz J, Mougel A, Mauré E, Conde E, Bruhns P, Guilleminault L, Gaudenzio N, Chen J, Gentek R, Reber LL. Science. 2021 Apr 9;372(6538):eabf2022. doi: 10.1126/science.abf2022. PMID: 33833094