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T Clavel, 20250306

Séminar Thomas Clavel, le 6 mars 2025

Thomas Clavel leads his independent research group at RWTH Aachen University Hospital (Germany)

thomasclavel

Gut microbiomes are essential for human health and play a causal role in the development multiple chronic diseases. However, despite 20 years of microbiome research, half of the microbial diversity in gut microbiomes is still unknown. This is a major obstacle for further development in the field. There is a renewed interest in anaerobic cultivation techniques, because they enable the description of novel taxonomic and functional diversity and provide the foundation for exploring microbial functions and defining the molecular mechanisms that underlie microbe-microbe and microbe-host interactions. In this seminar, Thomas Clavel will give an overview of the importance of studying gut microbiomes. Specific focus will be put on technical innovations to boost functional microbiome research using anaerobic cultivation. Specific examples on new taxonomic and functional diversity and how to design and use synthetic communities of cultured gut bacteria will be given.

tclavel

 

See also

  • A host-adapted auxotrophic gut symbiont induces mucosal immunodeficiency. Lu Q, Hitch TCA, Zhou JY, Dwidar M, Sangwan N, Lawrence D, Nolan LS, Espenschied ST, Newhall KP, Han Y, Karell PE, Salazar V, Baldridge MT, Clavel T, Stappenbeck TS. Science. 2024
  • Gut-liver axis: barriers and functional circuits. Pabst O, Hornef MW, Schaap FG, Cerovic V, Clavel T, Bruns T. Nat Rev Gastroenterol Hepatol. 2023
  • Enhanced cultured diversity of the mouse gut microbiota enables custom-made synthetic communities. Afrizal A, Jennings SAV, Hitch TCA, Riedel T, Basic M, Panyot A, Treichel N, Hager FT, Wong EO, Wolter B, Viehof A, von Strempel A, Eberl C, Buhl EM, Abt B, Bleich A, Tolba R, Blank LM, Navarre WW, Kiessling F, Horz HP, Torow N, Cerovic V, Stecher B, Strowig T, Overmann J, Clavel T. Cell Host Microbe. 2022
  • A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity. Wylensek D, Hitch TCA, Riedel T, Afrizal A, Kumar N, Wortmann E, Liu T, Devendran S, Lesker TR, Hernández SB, Heine V, Buhl EM, M D'Agostino P, Cumbo F, Fischöder T, Wyschkon M, Looft T, Parreira VR, Abt B, Doden HL, Ly L, Alves JMP, Reichlin M, Flisikowski K, Suarez LN, Neumann AP, Suen G, de Wouters T, Rohn S, Lagkouvardos I, Allen-Vercoe E, Spröer C, Bunk B, Taverne-Thiele AJ, Giesbers M, Wells JM, Neuhaus K, Schnieke A, Cava F, Segata N, Elling L, Strowig T, Ridlon JM, Gulder TAM, Overmann J, Clavel T. Nat Commun. 2020
  • Sequence and cultivation study of Muribaculaceae reveals novel species, host preference, and functional potential of this yet undescribed family. Lagkouvardos I, Lesker TR, Hitch TCA, Gálvez EJC, Smit N, Neuhaus K, Wang J, Baines JF, Abt B, Stecher B, Overmann J, Strowig T, Clavel T. Microbiome. 2019 

Modification date: 27 February 2025 | Publication date: 27 February 2025 | By: VTI