Original Articles (NGN team members in bold ; members of other Toxalim teams in italic)


Ilchmann-Diounou H, Olier M, Lencina C, Riba A, Barretto S, Nankap M, Sommer C, Guillou H, Ellero-Simatos S, Guzylack-Piriou L, Théodorou V, Ménard S. Early life stress induces type 2 diabetes-like features in ageing mice. Brain Behav Immun. 2019 Aug;80:452-463. doi: 10.1016/j.bbi.2019.04.025.

Kamphuis JBJ, Guiard B, Leveque M, Olier M, Jouanin I, Yvon S, Tondereau V, Rivière P, Guéraud F, Chevolleau S, Noguer-Meireles MH, Martin JF, Debrauwer L, Eutamène H, Theodorou V. Lactose and Fructo-oligosaccharides Increase Visceral Sensitivity in Mice via Glycation Processes, Increasing Mast Cell Density in Colonic Mucosa. Gastroenterology. 2019 Nov 8. pii: S0016-5085(19)41528-X. doi: 10.1053/j.gastro.2019.10.037.

Martin OCB, Olier M, Ellero-Simatos S, Naud N, Dupuy J, Huc L, Taché S, Graillot V, Levêque M, Bézirard V, Héliès-Toussaint C, Estrada FBY, Tondereau V,  Lippi Y, Naylies C, Peyriga L, Canlet C, Davila AM, Blachier F, Ferrier L, Boutet-Robinet E, Guéraud F, Théodorou V, Pierre FHF. Haem iron reshapes colonic luminal environment: impact on mucosal homeostasis and microbiome through aldehyde formation. Microbiome. 2019 May 6;7(1):72. doi:10.1186/s40168-019-0685-7.

Rincel M, Olier M, Minni A, de Oliveira CM, Matime Y, Gaultier E, Grit I, Helbling JC, Costa AM, Lépinay A, Moisan MP, Layé S, Ferrier L, Parnet P, Theodorou V, Darnaudéry M. Pharmacological restoration of gut barrier function in stressed neonates partially reverses long-term alterations associated with maternal separation. Psychopharmacology (Berl). 2019 May;236(5):1583-1596. doi: 10.1007/s00213-019-05252-w.

Yvon S, Schwebel L, Belahcen L, Tormo H, Peter M, Haimoud-Lekhal DA, Eutamene H, Jard G. Effects of thermized donkey milk with lysozyme activity on altered gut barrier in mice exposed to water-avoidance stress. J Dairy Sci. 2019 Sep;102(9):7697-7706. doi: 10.3168/jds.2019-16642.

Maes E, Sadovskaya I, Lévêque M, Elass-Rochard E, Payré B, Grard T, Théodorou V, Guérardel Y, Mercier-Bonin M. Structure and biological activities of a hexosamine-rich cell wall polysaccharide isolated from the probiotic Lactobacillus farciminis. Glycoconj J. 2019 Feb;36(1):39-55. doi:10.1007/s10719-018-09854-y.

Sundin J, Nordlander S, Eutamene H, Alquier-Bacquie V, Cartier C, Theodorou V, Le Nevé B, Törnblom H, Simrén M, Öhman L. Colonic mast cell numbers, symptom profile, and mucosal expression of elements of the epithelial barrier in irritable bowel syndrome. Neurogastroenterol Motil. 2019 Sep 13:e13701. doi:10.1111/nmo.13701.


Mercier-Bonin M, Despax B, Raynaud P, Houdeau E, Thomas M. Mucus and microbiota as emerging players in gut nanotoxicology: The example of dietary silver and titanium dioxide nanoparticles. Crit Rev Food Sci Nutr. 2018 Apr 13;58(6):1023-1032. doi: 10.1080/10408398.2016.1243088.

Eutamene H, Beaufrand C, Harkat C, Theodorou V. The role of mucoprotectants in the management of gastrointestinal disorders. Expert Rev Gastroenterol Hepatol. 2018 Jan;12(1):83-90. doi: 10.1080/17474124.2018.1378573.

Theodorou V. Probiotics, stress and Irritable Bowel Syndrome (2018). Phytothérapie. 16:320-325.

Maresca M, Pinton P, Ajandouz EH, Menard S, Ferrier L, Oswald IP. Overview and Comparison of Intestinal Organotypic Models, Intestinal Cells, and Intestinal Explants Used for Toxicity Studies. Curr Top Microbiol Immunol. 2018 Sep 28. doi: 10.1007/82_2018_142.

Gillois K, Lévêque M, Théodorou V, Robert H, Mercier-Bonin M. Mucus: An Underestimated Gut Target for Environmental Pollutants and Food Additives. Microorganisms. 2018 Jun 15;6(2). pii: E53. doi: 10.3390/microorganisms6020053.

Riba A, Olier M, Lacroix-Lamandé S, Lencina C, Bacquié V, Harkat C, Van Langendonck N, Gillet M, Cartier C, Baron M, Sommer C, Mallet V, Zill M, Robert H, Laurent F, Ellero-Simatos S, Théodorou V, Ménard S. Early life stress in mice  is a suitable model for Irritable Bowel Syndrome but does not predispose to colitis nor increase susceptibility to enteric infections. Brain Behav Immun. 2018 Oct;73:403-415. doi: 10.1016/j.bbi.2018.05.024.

Yvon S, Olier M, Leveque M, Jard G, Tormo H, Haimoud-Lekhal DA, Peter M, Eutamène H. Donkey milk consumption exerts anti-inflammatory properties by normalizing antimicrobial peptides levels in Paneth's cells in a model of ileitis in mice. Eur J Nutr. 2018 Feb;57(1):155-166. doi: 10.1007/s00394-016-1304-z. 

Boulete IM, Thadi A, Beaufrand C, Patwa V, Joshi A, Foss JA, Eddy EP, Eutamene H, Palejwala VA, Theodorou V, Shailubhai K. Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models. World J Gastroenterol. 2018 May 7;24(17):1888-1900. doi:10.3748/wjg.v24.i17.1888.

Ait-Belgnaoui A, Payard I, Rolland C, Harkat C, Braniste V, Théodorou V, Tompkins TA. Bifidobacterium longum and Lactobacillus helveticus Synergistically Suppress Stress-related Visceral Hypersensitivity Through Hypothalamic-Pituitary-Adrenal Axis Modulation. J Neurogastroenterol Motil. 2018 Jan 30;24(1):138-146. doi: 10.5056/jnm16167.

Talbot P, Radziwill-Bienkowska JM, Kamphuis JBJ, Steenkeste K, Bettini S, Robert V, Noordine ML, Mayeur C, Gaultier E, Langella P, Robbe-Masselot C, Houdeau E, Thomas M, Mercier-Bonin M. Food-grade TiO(2) is trapped by intestinal mucus in vitro but does not impair mucin O-glycosylation and short-chain fatty acid synthesis in vivo: implications for gut barrier protection. J Nanobiotechnology. 2018 Jun 19;16(1):53. doi: 10.1186/s12951-018-0379-5.

Radziwill-Bienkowska JM, Talbot P, Kamphuis JBJ, Robert V, Cartier C, Fourquaux I, Lentzen E, Audinot JN, Jamme F, Réfrégiers M, Bardowski JK, Langella P, Kowalczyk M, Houdeau E, Thomas M, Mercier-Bonin M. Toxicity of Food-Grade TiO(2) to Commensal Intestinal and Transient Food-Borne Bacteria: New Insights Using Nano-SIMS and Synchrotron UV Fluorescence Imaging. Front Microbiol. 2018 Apr 24;9:794. doi: 10.3389/fmicb.2018.00794. eCollection 2018.

Lukowicz C, Ellero-Simatos S, Régnier M, Polizzi A, Lasserre F, Montagner A,  Lippi Y, Jamin EL, Martin JF, Naylies C, Canlet C, Debrauwer L, Bertrand-Michel J, Al Saati T, Théodorou V, Loiseau N, Mselli-Lakhal L, Guillou H, Gamet-Payrastre L. Metabolic Effects of a Chronic Dietary Exposure to a Low-Dose  Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor. Environ Health Perspect. 2018 Jun 25;126(6):067007. doi: 10.1289/EHP2877.

Bautzova T, Hockley JRF, Perez-Berezo T, Pujo J, Tranter MM, Desormeaux C, Barbaro MR, Basso L, Le Faouder P, Rolland C, Malapert P, Moqrich A, Eutamene H, Denadai-Souza A, Vergnolle N, Smith ESJ, Hughes DI, Barbara G, Dietrich G, Bulmer DC, Cenac N. 5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein-coupled receptor D. Sci Signal. 2018 Dec 18;11(561). pii: eaal2171. doi: 10.1126/scisignal.aal2171.

Régnier M, Polizzi A, Lukowicz C, Smati S, Lasserre F, Lippi Y, Naylies C, Laffitte J, Bétoulières C, Montagner A, Ducheix S, Gourbeyre P, Ellero-Simatos S, Menard S, Bertrand-Michel J, Al Saati T, Lobaccaro JM, Burger HM, Gelderblom WC,  Guillou H, Oswald IP, Loiseau N. The protective role of liver X receptor (LXR) during fumonisin B1-induced hepatotoxicity. Arch Toxicol. 2019 Feb;93(2):505-517.doi: 10.1007/s00204-018-2345-2.

Da Silva S, Keita ÅV, Mohlin S, Påhlman S, Theodorou V, Påhlman I, Mattson JP, Söderholm JD. A Novel Topical PPARγ Agonist Induces PPARγ Activity in Ulcerative  Colitis Mucosa and Prevents and Reverses Inflammation in Induced Colitis Models. Inflamm Bowel Dis. 2018 Mar 19;24(4):792-805. doi: 10.1093/ibd/izx079.

Ringot-Destrez B, D'Alessandro Z, Lacroix JM, Mercier-Bonin M, Léonard R, Robbe-Masselot C. A Sensitive and Rapid Method to Determin the Adhesion Capacity of Probiotics and Pathogenic Microorganisms to Human Gastrointestinal Mucins. Microorganisms. 2018 May 29;6(2). pii: E49. doi: 10.3390/microorganisms6020049.

Fernandez N, Wrzosek L, Radziwill-Bienkowska JM, Ringot-Destrez B, Duviau MP,  Noordine ML, Laroute V, Robert V, Cherbuy C, Daveran-Mingot ML, Cocaign-Bousquet  M, Léonard R, Robbe-Masselot C, Rul F, Ogier-Denis E, Thomas M, Mercier-Bonin M. Characterization of Mucus-Related Properties of Streptococcus thermophilus: From  Adhesion to Induction. Front Physiol. 2018 Jul 24;9:980. doi:10.3389/fphys.2018.00980.

Malaisé Y, Ménard S, Cartier C, Lencina C, Sommer C, Gaultier E, Houdeau E, Guzylack-Piriou L. Consequences of bisphenol a perinatal exposure on immune responses and gut barrier function in mice. Arch Toxicol. 2018 Jan;92(1):347-358. doi: 10.1007/s00204-017-2038-2. Epub 2017 Jul 21.


Bettini S, Boutet-Robinet E, Cartier C, Coméra C, Gaultier E, Dupuy J, Naud N, Taché S, Grysan P, Reguer S, Thieriet N, Réfrégiers M, Thiaudière D, Cravedi JP,  Carrière M, Audinot JN, Pierre FH, Guzylack-Piriou L, Houdeau E. Food-grade TiO(2) impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon. Sci Rep. 2017 Jan 20;7:40373. doi: 10.1038/srep40373.

Olier M, Sekkal S, Harkat C, Eutamene H, Theodorou V. Evaluation of reticulated gelatin-hibiscus-propolis against intestinal commensal species commonly associated with urinary tract infections. Future Microbiol. 2017 May;12:505-513. doi: 10.2217/fmb-2016-0175.

Wells JM, Brummer RJ, Derrien M, MacDonald TT, Troost F, Cani PD, Theodorou V, Dekker J, Méheust A, de Vos WM, Mercenier A, Nauta A, Garcia-Rodenas CL. Homeostasis of the gut barrier and potential biomarkers. Am J Physiol Gastrointest Liver Physiol. 2017 Mar 1;312(3):G171-G193. doi:10.1152/ajpgi.00048.2015.

Robert H, Payros D, Pinton P, Théodorou V, Mercier-Bonin M, Oswald IP. Impact of mycotoxins on the intestine: are mucus and microbiota new targets? J Toxicol Environ Health B Crit Rev. 2017;20(5):249-275. doi:10.1080/10937404.2017.1326071.

Mercier-Bonin M, Chapot-Chartier MP. Surface Proteins of Lactococcus lactis: Bacterial Resources for Muco-adhesion in the Gastrointestinal Tract. Front Microbiol. 2017 Nov 23;8:2247. doi: 10.3389/fmicb.2017.02247.

Laroute V, Tormo H, Couderc C, Mercier-Bonin M, Le Bourgeois P, Cocaign-Bousquet M, Daveran-Mingot ML. From Genome to Phenotype: An Integrative Approach to Evaluate the Biodiversity of Lactococcus lactis. Microorganisms. 2017 May 19;5(2). pii: E27. doi: 10.3390/microorganisms5020027.

Riba A, Olier M, Lacroix-Lamandé S, Lencina C, Bacquié V, Harkat C, Gillet M, Baron M, Sommer C, Mallet V, Salvador-Cartier C, Laurent F, Théodorou V, Ménard S. Paneth Cell Defects Induce Microbiota Dysbiosis in Mice and Promote Visceral Hypersensitivity. Gastroenterology. 2017 Dec;153(6):1594-1606.e2.doi:10.1053/j.gastro.2017.08.044.

Kamphuis JBJ, Mercier-Bonin M, Eutamène H, Theodorou V. Mucus organisation is  shaped by colonic content; a new view. Sci Rep. 2017 Aug 17;7(1):8527. doi: 10.1038/s41598-017-08938-3.

Malaisé Y, Menard S, Cartier C, Gaultier E, Lasserre F, Lencina C, Harkat C, Geoffre N, Lakhal L, Castan I, Olier M, Houdeau E, Guzylack-Piriou L. Gut dysbiosis and impairment of immune system homeostasis in perinatally-exposed mice to Bisphenol A precede obese phenotype development. Sci Rep. 2017 Nov 3;7(1):14472. doi: 10.1038/s41598-017-15196-w.

Eutamène H, Garcia-Rodenas CL, Yvon S, d'Aldebert E, Foata F, Berger B, Sauser J, Theodorou V, Bergonzelli G, Mas E. Luminal contents from the gut of colicky infants induce visceral hypersensitivity in mice. Neurogastroenterol Motil. 2017 Apr;29(4). doi: 10.1111/nmo.12994.

Radziwill-Bienkowska JM, Robert V, Drabot K, Chain F, Cherbuy C, Langella P,  Thomas M, Bardowski JK, Mercier-Bonin M, Kowalczyk M. Contribution of plasmid-encoded peptidase S8 (PrtP) to adhesion and transit in the gut of Lactococcus lactis IBB477 strain. Appl Microbiol Biotechnol. 2017 Jul;101(14):5709-5721. doi: 10.1007/s00253-017-8334-1. Epub 2017 May 24.

Vollnhals F, Audinot JN, Wirtz T, Mercier-Bonin M, Fourquaux I, Schroeppel B,  Kraushaar U, Lev-Ram V, Ellisman MH, Eswara S. Correlative Microscopy Combining Secondary Ion Mass Spectrometry and Electron Microscopy: Comparison of Intensity-Hue-Saturation and Laplacian Pyramid Methods for Image Fusion. Anal Chem. 2017 Oct 17;89(20):10702-10710. doi: 10.1021/acs.analchem.7b01256.

Zinni M, Zuena AR, Marconi V, Petrella C, Fusco I, Giuli C, Canu N, Severini C, Broccardo M, Theodorou V, Lattanzi R, Casolini P. Maternal exposure to low levels of corticosterone during lactation protects adult rat progeny against TNBS-induced colitis: A study on GR-mediated anti-inflammatory effect and prokineticin system. PLoS One. 2017 Mar 7;12(3):e0173484. doi:10.1371/journal.pone.0173484.

Ducheix S, Montagner A, Polizzi A, Lasserre F, Régnier M, Marmugi A, Benhamed F, Bertrand-Michel J, Mselli-Lakhal L, Loiseau N, Martin PG, Lobaccaro JM, Ferrier L, Postic C, Guillou H. Dietary oleic acid regulates hepatic lipogenesis  through a liver X receptor-dependent signaling. PLoS One. 2017 Jul 21;12(7):e0181393. doi: 10.1371/journal.pone.0181393.


Annaházi A, Ábrahám S, Farkas K, Rosztóczy A, Inczefi O, Földesi I, Szűcs M, Rutka M, Theodorou V, Eutamene HBueno L, Lázár G, Wittmann T, Molnár T, Róka R. A pilot study on faecal MMP-9: a new noninvasive diagnostic marker of colorectal cancer. Br J Cancer 2016;114(7):787-92. 

Bessette C, Benoit B, Sekkal S, Bruno J, Estienne M, Leonil J, Ferrier L, Théodorou V, Plaisancié P. Protective effect of β-casofensin, a bioactive peptide from bovine β-casein, against indomethacin-induces intestinal lesions in rats. Mol Nutr Food Res 2016;60(4):823-33.

Castelain M, Duviau MP, Oxaran V, Schmitz P, Cocaign-Bousquet M, Loubière P, Piard JC, Mercier-Bonin M. Oligomerized backbone pilin helps piliated Lactococcus lactis to withstand shear flow. Biofouling. 2016;32(8):911-23.

Castelain M, Duviau MP, Canette A, Schmitz P, Loubière P, Cocaign-Bousquet M, Piard JC, Mercier-Bonin M. The Nanomechanical Properties of Lactococcus lactis Pili Are Conditioned by the Polymerized Backbone Pilin. PLoS One 2016;11(3):e0152053.

Eutamène H, Garcia-Rodenas CL, Yvon S, d'Aldebert E, Foata F, Berger B, Sauser J, Theodorou V, Bergonzelli G, Mas E. Luminal contents from the gut of colicky infants induce visceral hypersensitivity in mice. Neurogastroenterol Motil 2016 Dec 1. [Epub ahead of print]

Guellerin M, Passerini D, Fontagné-Faucher, Robert H, Gabriel V, Loux V, Klopp C, Le Loir Y, Coddeville M, Daveran-Mingot ML, Ritzenthaler P, Le Bourgeois P. Complete Genome Sequence of Lactococcus lactis subsp. lactis A12, a Strain Isolated from Wheat Sourdough. Genome Announc 2016; 4 (5) :e00692.

Miquel S, Martín R, Lashermes A, Gillet M, Meleine M, Gelot A, Eschalier A, Ardid D, Bermúdez-Humarán LG, Sokol H, Thomas M, Theodorou V, Langella P, Carvalho FA. Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models. Sci Rep 2016;6:19399.

Radziwill-Bienkowska JM, Le DT, Szczesny P, Duviau MP, Aleksandrzak-Piekarczyk T, Loubière P, Mercier-Bonin M, Bardowski JK, Kowalczyk M. Adhesion of the genome-sequenced Lactococcus lactis subsp. cremoris IBB477 strain is mediated by specific molecular determinants. Appl Microbiol Biotechnol 2016;100(22):9605-9617.

Rincel M, Lépinay AL, Delage P, Fioramonti JThéodorou V, Layé S, Darnaudéry M. Maternal high-fat diet prevents developmental programming by early-life stress. Transl Psychiatry 2016;6(11):e966.

Soayfane Z, Tercé F, Cantiello M, Robenek H, Nauze M, Bézirard V, Allart S, Payré B, Capilla F, Cartier C, Peres C, Al Saati T, Theodorou V, Nelson DW, Yen CL, Collet X, Coméra C. Exposure to dietary lipid leads to rapid production of cytosolic lipid droplets near the brush border membrane. Nutr Metab (Lond);2016;13:48. 

Yvon S, Olier M, Leveque M, Jard G, Tormo H, Haimoud-Lekhal DA, Peter M, Eutamène H. Donkey milk consumption exerts anti-inflammatory properties by normalizing antimicrobial peptides levels in Paneth's cells in a model of ileitis in mice. Eur J Nutr 2016;Aug 31. [Epub ahead of print]

Wang C, Zanna S, Frateur I, Despax B, Raynaud P, Mercier-Bonin M, Marcus P. BSA adsorption on a plasma-deposited silver nanocomposite film controls silver release: a QCM and XPS-based modelling. Surf Coat Technol 2016;307:1-8.


Da Silva S, Robbe-Masselot C, Raymond A, Mercade-Loubière M, Salvador-Cartier C, Ringot B, Léonard R, Fourquaux I, Ait-Belgnaoui A, Loubière P, Théodorou V, Mercier-Bonin M. Spatial localization and binding of the probiotic Lactobacillus farciminis to the rat intestinal mucosa: influence of chronic stress. PLoS One 2015;10(9):e0136048

Durand C, Pezet S, Eutamène H, Demarquay C, Mathieu N, Moussa L, Daudin R, Holler V, Sabourin JC, Milita F, François A, Théodorou V, Tamarat B, Benderitter M, Sémont A. Persistent visceral allodynia in rats exposed to colorectal irradiation is reverser by mesenchymal stromal cell treatment. Pain 2015;156(8):1465-76.

Martín R, Miquel S, Chain F, Natividad JM, Jury J, Lu J, Sokol H, Theodorou V, Bercik P, Verdu EF, Langella P, Bermúdez-Humarán LG. Faecalibacterium prausnitzii prevents physiological damages in a chronic low-grade inflammation murine model. BMC Microbiol 2015;15:67.

Secher T, Payros D, Brehin C, Boury M, Watrin C, Gillet M, Bernard-Cadenat I, Menard S, Theodorou V, Saoudi A, Olier M, Oswald E. Oral tolerance failure upon neonatal gut colonization with Escherichia coli producing the genotoxin colibactin. Infect Immun 2015;83(6):2420-9. 


Ménard SGuzylack-Piriou L, Lévêque M, Braniste V, Lencina C, Naturel M, Moussa L, Sekkal S, Harkat C, Gaultier EThéodorou VHoudeau E. Food intolerance at adulthood after perinatal exposure to the endocrine disruptor bisphenol A. FASEB J 2014;28(11):4893-900


Da Silva S, Robbe-Masselot C, Ait-Belgnaoui A, Mancuso A, Mercade-Loubière M, Cartier CGillet M, Ferrier L, Loubière P, Dague E, Théodorou V, Mercier-Bonin M. Stress disrupts intestinal mucus barrier in rats via mucin O-glycosylation shift: prevention by a probiotic treatment. Am J Physiol Gastrointest Liver Physiol 2014;307(4):G420-9

Ménard S, Guzylack-Piriou L, Lencina C, Leveque M, Naturel M, Sekkal S, Harkat C, Gaultier E, Olier M, Garcia-Villar RTheodorou V, Houdeau E.Perinatal exposure to a low dose of bisphenol A impaired systemic cellular immune response and predisposes young rats to intestinal parasitic infection. PLoS One 2014;9(11):e112752.

Moussaoui N, Braniste V, Ait-Belgnaoui A, Gabanou M, Sekkal S, Olier M, Théodorou VMartin PG, Houdeau E. Changes in intestinal glucocorticoid sensitivity in early life shape the risk of epithelial barrier defect in maternal-deprived rats. PLoS One, 9(2):e88382

Payros D, Sécher T, Boury M, Brehin C, Ménard S, Salvador-Cartier C, Ceevas-Ramos G, Watrin C, Marcq I, Nougayrède JP, Dubois D, Bedu A, Garnier F, Clermont O, Denamur E, Plaisancié P, Théodorou V, Fioramonti J, Olier M, Oswald E. Maternally acquired genotoxic Escherichia coli alters offspring's intestinal homeostasis. Gut Microbes 2014;5(3):313-25

Nébot-Vivinus M, Harkat C, Bzioueche H, Cartier C, Plichon-Dainese R, Moussa L, Eutamène H, Pishvaie D, Holowacz S, Seyrig C, Piche T, Théodorou V. A multispecies probiotic protects gut barrier function in experimental models. World J Gastroenterol 2014;20(22):6832-43

Ait-Belgnaoui A, Colom A, Braniste V, Ramalho L, Marrot ACartier C, Houdeau EThéodorou V, Tompkins T. Probiotic gut effect prevents the chronic psychological stress-induced brain activity abnormality in mice. Neurogastroenterol Motil 2014;26:510-20

Le Dréan G, Haure-Mirande V, Ferrier L, Bonnet C, Hulin P, De Coppet P, Segain JP. Visceral adipose tissue and leptin increase colonic epithelial tight-junction permeability via a RhoA-ROCK dependent pathway. FASEB J 2014;28:1059-70


Olivier I, Théodorou V, Valet P, Castan-Laurell I, Ferrier L, Eutamène H. Modifications of mesenteric adipose tissue during moderate experimental colitis. Life Sci 2014;94:1-7

Stockinger S, Albers T, Duerr CU, Ménard S, Pütsep K, Andersson M, Hornef MW. Interleukin-13-mediated Paneth cell degranulation and antimicrobial peptide release. J Innate Immun 2014;6:530-41

Marcq I, Martin P, Payros D, Cuevas-Ramos G, Boury M, Watrin C, Nougayrède JP, Olier M, Oswald E. The genotoxin colibactin exacerbates lymphopenia and decreases survival rate in mice infected with septicemic Escherichia coli. J Infect Dis 2014;210(2):285-94


Seyer A, Cantielo M, Bertrand-Michel J, Roques V, Nauze M, Bézirard V, Collet X, Touboul D, Brunelle A, Coméra C. Lipidomic and spatio-temporal imaging of fat by mass spectrometry in mice duodenum during lipid digestion. PLoS One 2013;8(4):e58224

Ducheix S, Montagner A, Polizzi A, Lasserre F, Marmugi A, Bertrand-Michel J, Podechard N, Saati TA, Chétiveaux M, Baron S, Boué J, Dietrich G, Mselli-Lakhal L, Costet P, Lobaccaro JM, Pineau T, Theodorou V, Postic C, Martin PG, Guillou H. Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the Liver X Receptor. J Hepatol 2013 (in press).


Petrella C, Giuli C, Broccardo M, Eutamene H, Cartier C, Leveque M, Bedini A, Spampinato S, Bueno L, Theodorou V, Improta G, Agostini S. Protective and worsening peripheral nociceptin/orphanin FQ receptor-mediated effect in a rat model of experimental colitis.  Pharmacol Res 2013;70(1):72-79.


Moussa L, Bézirard V, Salvador-Cartier C, Bacquié V, Lencina C, Lévêque M, Braniste V, Ménard S, Theodorou V, Houdeau E. A low dose of fermented soy germ alleviates gut barrier injury, hyperalgesia and faecal protease activity in a rat model of inflammatory bowel disease. PLoS One 2012;7(11):e49547.


Moussa L, Bézirard V, Salvador-Cartier C, Bacquié V, Houdeau E, Theodorou V.  A new soy germ fermented ingredient displays estrogenic and protease inhibitor activities able to prevent irritable bowel syndrome-like symptoms in stressed female rats. Clin Nutr 2013;32(1):51-8.


Annaházi A, Molnár T, Farkas K, Rosztóczy A, Izbéki F, Gecse K, Inczefi O, Nagy F, Földesi I, Szűcs M, Dabek MFerrier L, Theodorou V, Bueno L, Wittmann T, Róka R. Fecal MMP-9: A new noninvasive differential diagnostic and activity marker in ulcerative colitis. Inflamm Bowel Dis 2013;19(2):316-20.



Olier M, Marcq I, Salvador-Cartier C, Secher T, Dobrindt U, Boury M, Bacquié V, Pénary M, Gaultier E, Nougayrède JP, Fioramonti J, Oswald E. Genotoxicity of Escherichia coli Nissle 1917 strain cannot be dissociated from its probiotic activity.  Gut Microbes 2012;3(6):501-9. 

Ait-Belgnaoui A, Durand H, Cartier C, Chaumaz G, Eutamene H, Ferrier L, Houdeau E, Fioramonti J, Bueno L, Theodorou V. Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats. Psychoneuroendocrinology 2012;37(11):1885-95.

Agostini S, Goubern M, Tondereau V, Salvador-Cartier C, Bezirard V, Lévèque M, Keränen H, Theodorou V, Bourdu-Naturel S, Goupil-Feuillerat N, Legrain-Raspaud S, Eutamene H. A marketed fermented dairy product containing Bifidobacterium lactis CNCM I-2494 suppresses gut hypersensitivity and colonic barrier disruption induced by acute stress in rats. Neurogastroenterol Motil 2012;24(4):376-e172

Serino M, Luche E, Gres S, Baylac A, Bergé M, Cenac C, Waget A, Klopp P, Iacovoni J, Klopp C, Mariette J, Bouchez O, Lluch J, Ouarné F, Monsan P, Valet P, Roques C, Amar J, Bouloumié A, Theodorou V, Burcelin R. Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota. Gut 2012;61(4):543-53

Annaházi A, Dabek M, Gecse K, Salvador-Cartier CPolizzi A, Rosztóczy A, Róka R, Theodorou V, Wittmann T, Bueno L, Eutamene H. Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activated feed-back loop in visceral inflammatory pain. Neurogastroenterol Motil 2012;24(1):76-85, e13

Vivinus-Nébot M, Dainese R, Anty R, Saint-Paul MC, Nano JL, Gonthier N, Marjoux S, Frin-Mathy G, Bernard G, Hébuterne X, Tran A, Theodorou V, Piche T. Combination of allergic factors can worsen diarrheic irritable bowel syndrome: role of barrier defects and mast cells. Am J Gastroenterol 2012;107(1):75-81


Bai J, Khaldi S, Gargala G, Baishanbo A, François A, Ballet JJ, Ducrotté P, Fioramonti J, Favennec L, Le Goff L. Effects of octreotide on jejunal hypersensitivity triggered by Cryptosporidium parvum intestinal infection in an immunocompetent suckling rat model. Neurogastroenterol Motil 2011;23(11):1043-50, e499

Clermont O, Olier M, Hœde C, Diancourt L, Brisse S, Keroudean M, Glodt J, Picard B, Oswald E, Denamur E. Animal and human pathogenic Escherichia coli strains share common genetic backgrounds. Infect Genet Evol 2011;11(3):654-62. 

Dabek MFerrier LAnnahazi ABézirard VPolizzi ACartier CLevêque M, Roka R, Wittmann T, Theodorou VBueno L. Intracolonic infusion of fecal supernatants from ulcerative colitis patients triggers altered permeability and inflammation in mice: role of cathepsin G and Protease-Activated Receptor 4. Inflamm Bowel Dis 2011;17(6):1409-1. 

Olivier I, Theodorou V, Valet P, Castan-Laurell I, Guillou H, Bertrand-Michel J, Cartier C, Bézirard V, Ducroc R, Segain JP, Portier G, Kirzin S, Moreau J, Duffas JP, Ferrier LEutamène H. Is Crohn’s creeping fat an adipose tissue ? Inflamm Bowel Dis 2011;17(3):747-57.

Braniste V, Audebert M, Zalko D, Houdeau E. Bisphenol A in the Gut: Another Break in the Wall? In Multi-System Endocrine Disruption - Series: Research and Perspectives in Endocrine Interactions. Bourguignon J.-P., Jégou B., Kerdelhué B., Toppari J., Christen Y. (Eds.). Springer-Verlag Berlin Heidelberg 2011. pp127.

Clermont O, Olier M, Hœde C, Diancourt L, Brisse S, Keroudean M, Glodt J, Picard B, Oswald E, Denamur E. Animal and human pathogenic Escherichia coli strains share common genetic backgrounds. Infect Genet Evol 2011;11(3):654-62 [IF=3.223].


Dabek M, Ferrier L, Annahazi A, Bézirard V, Polizzi A, Cartier C, Levêque M, Roka R, Wittmann T, Theodorou V, Bueno L. Intracolonic infusion of fecal supernatants from ulcerative colitis patients triggers altered permeability and inflammation in mice: role of cathepsin G and Protease-Activated Receptor 4. Inflamm Bowel Dis 2011;17(6):1409-14 [IF=4.643].

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Olivier I, Theodorou V, Valet P, Castan-Laurell I, Guillou H, Bertrand-Michel J, Cartier C, Bézirard V, Ducroc R, Segain JP, Portier G, Kirzin S, Moreau J, Duffas JP, Ferrier L, Eutamène H. Is Crohn’s creeping fat an adipose tissue ? Inflamm Bowel Dis 2011;17(3):747-57 [IF=4.643].



Agostini S, Eutamene H,Cartier C, Broccardo M, Improta G, Houdeau E, Petrella C, Ferrier L, Theodorou V, Bueno L. Evidence of Central and Peripheral Sensitization in a Rat Model of Narcotic Bowel Like-Syndrome. Gastroenterology 2010;139(2):553-63 [IF=12.899].


Braniste V, Jouault A, Gaultier E, Polizzi A, Buisson-Brenac C, Leveque M, Martin PG, Theodorou V, Fioramonti J, Houdeau E. Impact of oral bisphenol A at reference doses on intestinal barrier function and sex differences after perinatal exposure in rats. Proc Natl Acad Sci U S A 2010;107(1):448-53 [IF=9.432].


Estienne M, Claustre J, Clain-Gardechaux G, Paquet A, Taché Y, Fioramonti J, Plaisancié P. Maternal deprivation alters epithelial secretory cell lineages in rat duodenum: role of CRF-related peptides. Gut 2010;59(6):744-51 [IF=9.357].

Eutamene H, Bradesi S, Larauche M, Theodorou V,Beaufrand C, Ohning G, Fioramonti J, Cohen M, Bryant AP, Kurtz C, Currie MG, Mayer EA, Bueno L. Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain. Neurogastroenterol Mot 2010;22(3):312-e84 [IF=3.568].

Ferrier L, Serradeil-Le Gal C, Schulte AM, Vasina V, Gaultier E, Schroedel S, Ursino MG, Chaumaz G, Pascal M, De Ponti F, Bueno L. Pro-inflammatory role of vasopressin through V1b receptors in hapten-induced experimental colitis in rodents : implication in IBD. Am J Physiol 2010; 299(6):G1298-307 [IF=3.258].


Grimoud J, Durand H, Courtin C, Monsan P, Ouarné F, Theodorou V, Roques C. In vitro screening of probiotic lactic acid bacteria and prebiotic glucooligosaccharides to select effective synbiotics. Anaerobe 2010;16(5):493-500 [IF=1.633].

Grimoud J, Durand H, de Souza S, Monsan P, Ouarné F, Theodorou V, Roques C. In vitro screening of probiotics and synbiotics according to anti-inflammatory and anti-proliferative effects. Int J Food Microbiol 2010;144(1):42-50 [IF=3.011].

Petrella C, Agostini S, Alema' GS, Casolini P, Carpino F, Giuli C, Improta G, Linari G, Petrozza V, Broccardo M. Cannabinoid agonist WIN55,212 in vitro inhibits interleukin-6 (IL-6) and monocyte chemo-attractant protein-1 (MCP-1) release by rat pancreatic acini and in vivo induces dual effects on the course of acute pancreatitis. Neurogastroenterol Mot 2010;22(11):1248-56 [IF=3.568].


Wittmann T, Paradowski L, Ducrotté P, Bueno L, Andro Delestrain MC. Clinical trial: the efficacy of alverine citrate/simeticone combination on abdominal pain/discomfort in irritable bowel syndrome--a randomized, double-blind, placebo-controlled study. Aliment Pharmacol Ther 2010;31(6):615-24 [IF=4.357].

Modification date: 08 June 2023 | Publication date: 15 July 2010 | By: VT - LF