The team "Metabolism of Xenobiotics" (MeX) addresses the metabolic effects of food contaminants, in particular the impact on health of mixtures of pesticides, at concentrations which can be made available through food to consumers.

The goal is to understand the cellular effects, mechanisms of action and seeking biomarkers of exposure.

This research is implemented through different approaches:

  • The study of metabolism and metabolic activation of these compounds.
  • Approaches in vitro on human cells of intestinal origin since the digestive tract tissue is likely to be exposed to these compounds.
  • Approaches in vivo in the mouse model on the impact of pesticide mixtures on hematopoiesis (clonogenicity, differentiation, signaling pathway), since hematopoietic cancers are diseases whose incidence is correlated with the professional use of pesticides...


In this folder

Thanks to the functional annotation of genomes and advances in metabolomics, it is now possible to study the metabolic network of an organism as a whole. Bioinformatics makes an indispensable contribution to each step leading to the overall analysis of a metabolic network, automated rebuilding of it in developing new algorithms and dedicated tools..
Metabolism of xenobiotics present in food and their effects on physiological functions
Test H2AX by In Cell Western
Food contaminants may lead either directly or after bio-activation to cellular damage, especially to DNA..

Modification date : 08 June 2023 | Publication date : 15 July 2010 | Redactor : DZ