Scientific Productions

Team members are in bold


  • Dabholkar A, Pandit S, Devkota R, Dhingra S, Lorber S, Puel O, Calbo AM. 2024. Role of the osaA gene in Aspergillus fumigatus development, secondary metabolism and virulence. J Fungi 10:103.


  • Garofalo M, Payros D, Penary M, Oswald E, Nougayrède JP, Oswald IP. 2022. A novel toxic effect of foodborne trichothecenes: The exacerbation of genotoxicity. Environ Pollut. 317:120625.
  • Schrenk D, Bignami M, Bodin L, Chipman JK, Del Mazo J, Grasl-Kraupp B, Hogstrand C, Leblanc JC, Nielsen E, Ntzani E, Petersen A, Sand S, Schwerdtle T, Vleminckx C, Wallace H, Daenicke S, Nebbia CS, Oswald IP, Rovesti E, Steinkellner H, Hoogenboom LR. 2023. Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry. EFSA J. 21(2):e07806. doi: 10.2903/j.efsa.2023.7806.
  • S.P. Sandesh, J. Zheng, Y. Yin, S. Lorber, O. Puel, S. Dhingra, E.A. Espeso, A.M. Calvo. 2023. Homeobox transcription factor HbxA influences expression of over one thousand genes in the model fungus Aspergillus nidulans. PlosOne.
  • Tahtah N, Zetina-Serrano C, Rocher O, Naylies C, Lippi Y, El Khoury A, Atoui A, Jamin EL, Oswald IP, Lorber S, Puel O. 2023. Implication of VelB in the development, pathogenicity, and secondary metabolism of Penicillium expansum. Postharvest Biol Technol. 195:112121.


  • Al Khoury A, El Khoury A, Rocher O, Hindieh P, Puel O, Maroun RG, Atoui A, Bailly JD. 2022. Inhibition of aflatoxin B1 synthesis in Aspergillus flavus by mate (Ilex paraguariensis), rosemary (Rosmarinus officinalis) and green tea (Camellia sinensis) extracts: relation with extract antioxidant capacity and fungal oxidative stress response modulation. Molecules. 27(23):8550.
  • Al-Ayoubi C, Oules J, Person E, Bruel S, Bouville A, Pinton P, Oswald IP, Jamin EL, Puel O, Soler L. Metabolism of versicolorin A, a genotoxic precursor of aflatoxin B1: Characterization of metabolites using in vitro production of standards. 2022. Food Chem Toxicol. 2022 113272. doi: 10.1016/j.fct.2022.113272.
  • Dopavogui L, Polizzi A, Fougerat A, Gourbeyre P, Terciolo C, Klement W, Pinton P, Laffite J, Cossalter AM, Bailly JD, Puel O, Lippi Y, Naylies C, Guillou H, Oswald IP, Loiseau N. Tissular genomic responses to oral FB1 exposure in pigs. Toxins (Basel). 2022. 14:83.
  • Garofalo M, Payros D, Oswald E, Nougayrède JP, Oswald IP. 2022. The food-borne contaminant deoxynivalenol exacerbates DNA damage caused by a broad spectrum of genotoxic agents. Sci Total Environ. 153280. doi: 10.1016/j.scitotenv.2022.153280.
  • Hasuda AL, Person E, Khoshal AK, Bruel S, Puel S, Oswald IP, Bracarense APFRL, Pinton P. 2022. Deoxynevalenol induces apoptosis and inflammation in the liver: Analysis using precision-cut liver slices. Food Chem Toxicol. 163:112930.
  • Hernandez C, Cadenillas L, Mathieu C, Bailly JD, Durrieu V. Preservation of Mimosa tenuiflora antiaflatoxigenic activity using microencapsulation by spray-drying. 2022. Molecules. 27:496.
  • Mussard E, Lencina C, Gallo L, Barilly C, Poli M, Feve K, Albin M, Cauquil L, Knudsen C, Achard C, Devailly G, Soler L, Combes S, Beaumont M. 2022. The phenotype of the gut region is more stably retained than developmental stage in piglet intestinal organoids. Front Cell Dev Biol. 10:983031.
  • Pierron A, Neves M, Puel S, Lippi Y, Soler L, Miller JD, Oswald IP. 2022. Intestinal toxicity of the new type A trichothecenes, NX and 3ANX. Chemosphere. 288:132415.
  • Puel O, Cramer B, Oswald IP, Humpf H-U. 2022. From the laboratory bench to the lecture hall: latest findings from mycotoxin research presented at the 43rd Mycotoxin Workshop. Mycotoxin Res. 38(3):163-165.
  • Schrenk D, Bignami M, Bodin L, Chipman JK, Del Mazo J, Grasl-Kraupp B, Hogstrand C, Leblanc J-C, Nielsen E, Ntzani E, Petersen A, Sand S, Schwerdtle T, Vleminckx C, Wallace H, Daenicke S, Nebbia CS, Oswald IP, Rovesti E, Steinkellner H, Hoogenboom LR. 2022. Assessment of information as regards the toxicity of fumonisins for pigs, poultry and horses. EFSA J. 20:e07534.
  • Schrenk D, Bignami M, Bodin L, Chipman JK, Del Mazo J, Grasl-Kraupp B, Hogstrand C, Leblanc JC, Nielsen E, Ntzani E, Petersen A, Sand S, Schwerdtle T, Vleminckx C, Wallace H, Daenicke S, Nebbia CS, Oswald IP, Rovesti E, Steinkellner H, Hoogenboom LR. 2022. Assessment of information as regards the toxicity of T-2 and HT-2 toxin for ruminants. EFSA J. 20:e07564.
  • Soler L, Miller I, Terciolo C, Hummel K, Nöbauer K, Neves M, Oswald IP. 2022. Exposure of intestinal explants to NX, but not to DON, enriches the secretome in mitochondrial proteins. Arch Toxicol. 96:2609-2619.


  • Al Khoury A, Sleiman R, Atoui A, Hindieh P, Maroun RG, Bailly JD, El Khoury A. 2021. Antifungal and anti-aflatoxigenic properties of organs of Cannabis sativa L.: relation to phenolic content and antioxidant capacities. Arch Microbiol. 203:4485-4492.
  • Budin C, Man HY, Al-Ayoubi C, Puel S, van Vugt-Lussenburg BMA, Brouwer A, Oswald IP, van der Burg B, Soler L. 2021. Versicolorin A enhances the genotoxicity of aflatoxin B1 in human liver cells by inducing the transactivation of the Ah-receptor. Food Chem Toxicol. 153: 112258.
  • Carvajal-Campos A, Manizan AL, Montet D, Lorber S, Puel O, Brabet C. Biodiversity of aflatoxigenic Aspergillus section Flavi species according to food matrices and geographic areas. In Mycotoxins in Food and Beverages: Innovations and Advances Part I, Montet D, Brabet C, Schorr-Galindo S, Ray, RC, Eds; Food Biology series, Boca Raton: CRC press, USA, 2021, Chap 4, pp. 69-115.
  • Coarer M, Puel O, Lorber S, Puel S, Guichard H, Le Maguet J, Corroyer N, Camponovo A, Boiry S, Sabaty M, Caboulet D, Solanet D. 2021. Mycotoxines majeures et émergentes dans les filières cidre et vin: observatoire, lutte biologique au champ et devenir au cours des procédés. Innov Agron. 82: 246-261.
  • Costes LH, Lippi Y, Naylies C, Jamin EL, Genthon C, Bailly S, Oswald IP, Bailly JD, Puel O. 2021. The solvent dimethyl sulfoxide affects physiology, transcriptome and secondary metabolism of Aspergillus flavus. J Fungi 7:1055.
  • Hernandez C, Cadenillas L, Maghubi AE, Caceres I, Durrieu V, Mathieu C, Bailly JD. 2021. Mimosa tenuiflora aqueous extract: role of condensed tannins in anti-aflatoxin B1 activity in Aspergillus flavus. Toxins. 13:391.
  • Luo S, Terciolo C, Neves M, Puel S, Naylies C, Lippi Y, Pinton P, Oswald IP. 2021. Comparative sensitivity of proliferative and differentiated intestinal epithelial cells to the food contaminant, deoxynivalenol. Environ Pollut. 277: 116818.
  • Maresca M, Pinton P, Ajandouz EH, Menard S, Ferrier L, Oswald IP. 2019. Overview and comparison of intestinal organotypic models, intestinal cells, and intestinal explants used for toxicity studies. Curr Top Microbiol Immunol. 430: 247-264.
  • Nagl V, Grenier B, Pinton P, Ruczizka U, Dippel M, Bünger M, Oswald IP, Soler L. 2021. Exposure to zearalenone leads to metabolic disruption and changes in circulating adipokines in pigs. Toxins 13:790.
  • Novak B, Lopes Hasuda A, Ghanbari M, Mayumi Maruo V, Bracarense APFRL, Neves M, Emsenhuber C, Wein S, Oswald IP, Pinton P, Schatzmayr D. 2021. Effects of Fusarium metabolites beauvericin and enniatins alone or in mixture with deoxynivalenol on weaning piglets. Food Chem Toxicol. 27:112719.
  • Payros D, Alassane-Kpembi I, Laffitte J, Lencina C, Neves M, Bracarense AP, Pinton P, Ménard S, Oswald IP. 2021. Dietary exposure to the food contaminant deoxynivalenol triggers colonic breakdown by activating the mitochondrial and the death receptor pathways. Mol Nutr Food Res. 65:e2100191.
  • Payros D, Garofalo M, Pierron A, Soler-Vasco L, Al-Ayoubi C, Maruo VM, Alassane-Kpembi I, Pinton P, Oswald IP. Les mycotoxines en alimentation humaine : un défi pour la recherche. Cah Nutr Diet. 56:170-183.
  • Peillod C, Laborde M, Travel A, Mika A, Bailly JD, Cleva D, Boissieu C, Le Guennec J, Albaric O, Labrut S, Froment P, Tardieu D, Guerre P. 2021. Toxic effects of fumonisins, deoxynivalenol and zearalenone alone and in combination in ducks fed the maximum EUTolerated Level. Toxins. 13:152.
  • Schambri P, Brunet S, Bailly JD, Kleiber D, Levasseur-Garcia C. 2021. Effect of popcorn (Zea mays var. everta) popping mode (microwave, hot oil, and hot air) on fumonisins and deoxynivalenol contamination levels. Toxins. 13:486.
  • Tremblay-Franco M, Canlet C, Pinton P, Lippi Y, Gautier R, Naylies C, Neves M, Oswald IP, Debrauwer L, Alassane-Kpembi I. 2021. Statistical Integration of 'Omics Data Increases Biological Knowledge Extracted from Metabolomics Data: Application to Intestinal Exposure to the Mycotoxin Deoxynivalenol. Metabolites. 11:407.


  • Alassane-Kpembi I, Canlet C, Tremblay-Franco M, Jourdan F, Chalzaviel M, Pinton P, Cossalter AM, Achard C, Castex M, Combes S, Bracarense APL, Oswald IP. 2020. 1H-NMR metabolomics response to a realistic diet contamination with the mycotoxin deoxynivalenol: Effect of probiotics supplementation. Food Chem Toxicol. 138: 111222.
  • Bracarense APFL, Pierron A, Pinton P, Gerez JR, Schatzmayr G, Moll WD, Zhou T, Oswald IP. 2020. Reduced toxicity of 3-epi-deoxynivalenol and de-epoxy-deoxynivalenol through deoxynivalenol bacterial biotransformation: In vivo analysis in piglets. Food Chem Toxicol. 140: 111241.
  • Caceres I, Al Khoury A, El Khoury R, Lorber S, Oswald IP, El Khoury A, Atoui A, Puel O, Bailly J-D. 2020. Genetic regulation of aflatoxin B1 biosynthesis: a review. Toxins 12. pii: E150.
  • Coarer M, Puel O, Lorber S, Puel S, Guichard H, Le Maguet J, Corroyer N, Camponovo A, Boiry S, Sabaty M, Caboulet D, Solanet D. 2021. Mycotoxines majeures et émergentes dans les filières cidre et vin: observatoire, lutte biologique au champ et devenir au cours des procédés. Innov Agron. 82: 246-261.
  • Dellafiora L, Oswald IP, Dorne JL, Galaverna G, Battilani P, Dall'Asta C. 2020. An in silico structural approach to characterize human and rainbow trout estrogenicity of mycotoxins: Proof of concept study using zearalenone and alternariol. Food Chem. 312: 126088.
  • EFSA Panel on Contaminants in the Food Chain (CONTAM), Schrenk D, Bignami M, Bodin L, Chipman JK, Del Mazo J, Grasl-Kraupp B, Hogstrand C, Hoogenboom LR, Leblanc JC, Nebbia CS, Nielsen E, Ntzani E, Petersen A, Sand S, Schwerdtle T, Vleminckx C, Marko D, Oswald IP, Piersma A, Routledge M, Schlatter J, Baert K, Gergelova P, Wallace H. Risk assessment of aflatoxins in food. EFSA J. 2020 18: e06040.
  • El Hajj Assaf C, Zetina-Serrano C, Tahtah N, El Khoury A, Atoui A, Oswald IP, Puel O, Lorber S. 2020. Regulation of secondary metabolism in the Penicillium genus. Int J Mol Sci. 21: 9462.
  • Gauthier T, Duarte-Hospital C, Vignard J, Boutet-Robinet E, Sulyok M, Snini SP, Alassane-Kpembi I, Lippi Y, Puel S, Oswald IP, Puel O. 2020. Versicolorin A, a precursor in aflatoxins biosynthesis, is a food contaminant toxic for human intestinal cells. Environ Int. 137: 105568.
  • Gutiérrez AM, Bassols A, Soler L, Piñeiro M. 2020. Editorial: Factors influencing biomarker range intervals in farm animals. Front Vet Sci. doi: 10.3389/fvets.2020.587741.
  • Lahjouji T, Bertaccini A, Neves M, Puel S, Oswald IP, Soler L. 2020. Acute exposure to zearalenone disturbs intestinal homeostasis by modulating the wnt/β-catenin signaling pathway. Toxins 12. pii: E113.
  • Leblois J, Zhang Y, Wavreille J, Uerlings J, Schroyen M, Sureda EA, Soyeurt H, Dehareng F, Grelet C, Oswald IP, Li B, Bindelle J, Zhang H, Everaert N. 2020. Effects of wheat bran applied to maternal diet on the intestinal architecture and immune gene expression in suckling piglets. Animals (Basel). 10: 2051.
  • Moroldo M, Munyaka PM, Lecardonnel J, Lemonnier G, Venturi E, Chevaleyre C, Oswald IP, Estellé J, Rogel-Gaillard C. 2020. Integrative analysis of blood and gut microbiota data suggests a non-alcoholic fatty liver disease (NAFLD)-related disorder in French SLAdd minipigs. Sci Rep. 10: 234.
  • Payros D, Ménard S, Laffitte J, Neves M, Tremblay-Franco M, Luo S, Fouche E, Snini SP, Theodorou V, Pinton P, Oswald IP. 2020. The food contaminant, deoxynivalenol, modulates the Thelper/Treg balance and increases inflammatory bowel diseases. Arch Toxicol. 94: 3173-3184.
  • Quéro L, Courault P, Cellière B, Lorber S, Jany JL, Puel O, Girard V, Vasseur V, Nodet P, Mounier J. 2020. Application of MALDI-TOF MS to species complex differentiation and strain typing of food related fungi: case studies with Aspergillus section Flavi species and Penicillium roqueforti isolates. Food Microbiol. 86: 103311.
  • Satterlee T, Nepal B, Lorber S, Puel O, Calvo A. 2020. The transcriptional regulator HbxA governs development, secondary metabolism and virulence in Aspergillus fumigatus. Appl. Environ. Microbiol. 86: e01779-19.
  • Schrenk D, Bignami M, Bodin L, Chipman JK, Del Mazo J, Grasl-Kraupp B, Hogstrand C, Hoogenboom LR, Leblanc JC, Nebbia CS, Nielsen E, Ntzani E, Petersen A, Sand S, Schwerdtle T, Vleminckx C, Marko D, Oswald IP, Piersma A, Routledge M, Schlatter J, Baert K, Gergelova P, Wallace H. 2020. Risk assessment of aflatoxins in food. EFSA Panel on Contaminants in the Food Chain (CONTAM). EFSA J. 18: e06040.
  • Silva JJ, Iamanaka BT, Ferranti LS, Massi FP, Taniwaki MH, Puel O, Lorber S, Frisvad JC, Fungaro MHP. 2020. Diversity within Aspergillus niger clade and description of a new species: Aspergillus vinaceus sp. nov. J Fungi 6: 371.
  • Soler L, Stella A, Seva J, Pallarés FJ, Lahjouji T, Burlet-Schiltz O, Oswald IP. 2020. Proteome changes induced by a short, non-cytotoxic exposure to the mycoestrogen zearalenone in the pig intestine. J Proteomics 224: 103842.
  • Uka V, Cary JW, Lebar MD, Puel O, De Saeger S, DiMavungu JD. 2020. Chemical repertoire and biosynthetic machinery of the Aspergillus flavus secondary metabolome: A review. Compr Rev Food Sci Food Saf 19: 2797-2842.
  • Vin K, Rivière G, Leconte S, Cravedi JP, Fremy JM, Oswald IP, Roudot AC, Vasseur P, Jean J, Hulin M, Sirot V. 2020. Dietary exposure to mycotoxins in the French infant total diet study. Food Chem Toxicol. 140: 111301.
  • Zetina-Serrano C, Rocher O, Naylies C, Lippi Y, Oswald IP, Lorber S, Puel O. 2020. The brlA gene deletion reveals that patulin biosynthesis is not related to conidiogenesis in Penicillium expansum. Int. J. Molec. Sci 21: 6660.


  • Alassane-Kpembi I, Pinton P, Oswald IP. 2019. Effects of mycotoxins on the intestine. Toxins 11. pii: E159.
  • Aupanun S, Poapolathep S, Phuektes P, Giorgi M, Zhang Z, Oswald IP, Poapolathep A. 2019. Individual and combined mycotoxins deoxynivalenol, nivalenol, and fusarenon-x induced apoptosis in lymphoid tissues of mice after oral exposure. Toxicon 165: 83-94.
  • Aupanun S, Phuektes P, Poapolathep S, Alassane-Kpembi I, Oswald IP, Poapolathep A. 2019. Cytotoxicity of deoxynivalenol, nivalenol, and fusarenon-x on jurkat human t cells: individual and combined effects of major trichothecenes type B. Toxicon 160: 29-37.
  • Garcia GR, Dogi CA, Poloni VL, Fochesato AS, De Moreno de Leblanc A, Cossalter AM, Payros D, Oswald IP, Cavaglieri LR. 2019. Beneficial effects of Saccharomyces cerevisiae rc016 in weaned piglets: in vivo and ex vivo analysis. Benef Microbes. 10: 33-42.
  • Graziani F, Pinton P, Olleik H, Pujol A, Nicoletti C, Sicre M, Quinson N, Ajandouz EH, Perrier J, Di Pasquale E, Oswald IP, Maresca M. 2019. Deoxynivalenol inhibits the expression of trefoil factors (TFF) by intestinal human and porcine goblet cells. Arch Toxicol. 93: 1039-1049.
  • Hautbergue T, Jamin EL, Costantino R, Tadrist S, Meneghetti L, Tabet JC, Debrauwer L, Oswald IP, Puel O. 2019. Combination of isotope labeling and molecular networking of tandem mass spectrometry data to reveal 69 unknown metabolites produced by Penicillium nordicum. Anal Chem. 91: 12191-12202.
  • Khoshal AK , Novak B, Martin PGP, Jenkins T, Neves M, Schatzmayr G, Oswald IP, Pinton P. 2019. Co-occurrence of DON and emerging mycotoxins in worldwide finished pig feed and their combined toxicity in intestinal cells. Toxins 11. pii: E727.
  • Lohmar J, Puel O, Cary J, Calvo A. 2019. The rtfA gene regulates plant and animal pathogenesis and secondary metabolism in Aspergillus flavus. Appl. Environ. Microbiol. pii: AEM.02446-18.
  • Luo S, Terciolo C, Bracarense APFL, Payros D, Pinton P, Oswald IP. 2019. In vitro and in vivo effects of a mycotoxin, deoxynivalenol, and a trace metal, cadmium, alone or in a mixture on the intestinal barrier. Environ Int. 132: 105082.
  • Makhlouf J, Carvajal-Campos A, Querin A, Tadrist S, Puel O, Lorber S, Oswald IP, Hamze M, Bailly JD, Bailly S. 2019. Biodiversity of Aspergillus section Flavi in spices marketed in Lebanon. Sci Reports 9: 5263.
  • Metayer JP, Travel A, Mika A, Bailly JD, Cleva D, Boissieu C, Guennec JL, Froment P, Albaric O, Labrut S, Lepivert G, Marengue E, Tardieu D, Guerre P. 2019. Lack of toxic interaction between fusariotoxins in broiler chickens fed throughout their life at the highest level tolerated in the European Union. Toxins 11. pii: E455.
  • Nepal B, Myers R, Lohmar JM, Puel O, Thompson B, Van Cura M, Calvo AM. 2019. Characterization of the putative polysaccharide synthase CpsA and its effects on the virulence of the human pathogen Aspergillus fumigatus. PLoS One 14: 0216092.
  • Régnier M, Polizzi A, Lukowicz C, Smati S, Lasserre F, Lippi Y, Nayliès C, Laffitte J, Bétoulières C, Montagner A, Ducheix S, Gourbeyre P, Ellero-Simatos S, Ménard S, Bertrand-Michel J, Al Saati T, Lobaccaro JM, Burger HM, Gelderblom WC, Guillou H, Oswald IP, Loiseau N. 2019. The protective role of liver X receptor (LXR) during fumonisin B1-induced hepatotoxicity. Arch Toxicol. 93: 505-517.
  • Roubeau Dumont E, Larue C, Lorber S, Gryta H, Billoir E, Gross E, Elger A. 2019. Does intraspecific variability matter in ecological risk assessment? Investigation of genotypic variations in three macrophyte species exposed to copper. Aquat Toxicol. 211: 29-37.
  • Silva JJ, Puel O, Lorber S, Ferranti LS, Ortiz LF, Taniwaki MH, Iamanaka BT, Pelegrinelli Fungaro MHP. 2019. Occurrence and diversity of Aspergillus in commercial yerba mate elaborated for the Brazilian beverage ‘chimarrão’. Food Res Int. 121: 940-946.
  • Steinkellner H, Binaglia M, Dall'Asta C, Gutleb AC, Metzler M, Oswald IP, Parent-Massin D, Alexander J. 2019. Combined hazard assessment of mycotoxins and their modified forms applying relative potency factors: Zearalenone and T2/HT2 toxin. Food Chem Toxicol. 131: 110599.
  • Terciolo C, Bracarense AP, Souto PCMC, Cossalter AM, Dopavogui L, Loiseau N , Carlos A. F. Oliveira CAF , Pinton P, Oswald IP. 2019. Fumonisins at doses below EU regulatory limits induce histological alterations in piglets. Toxins 11. pii: E548.
  • Travel A, Metayer JP, Mika A, Bailly JD, Cleva D, Boissieu C, Le Guennec J, Albaric O, Labrut S, Lepivert G, Marengue E, Froment P, Tardieu D, Guerre P. 2019. Toxicity of fumonisins, deoxynivalenol, and zearalenone alone and in combination in turkeys fed with the maximum european union-tolerated level. Avian Dis. 63: 703-712.
  • Waret-Szkuta A, Larraillet L, Oswald IP, Legrand X, Guerre P, Martineau GP. 2019. Unusual acute neonatal mortality and sow agalactia linked with ergot alkaloid contamination of feed. Porcine Health Manag. 5: 24.
  • Yu X, Martin PGP, Michaels SD. 2019. BORDER proteins protect expression of neighboring genes by promoting 3’ Pol II pausing in plants. Nat Commun. 10: 4359.


  • Alassane-Kpembi I, Pinton P, Hupé JF, Neves M, Lippi Y, Combes S, Castex M, Oswald IP. 2018. Saccharomyces cerevisiae Boulardii reduces the Deoxynivalenol-induced alteration of the intestinal transcriptome. Toxins 10. pii: E199.
  • Aleksic B, Draghi M, Gehin E, Ha Tl, Bailly JD, Crepon K, Moularat S, Robine E. 2018. Are VOCs an efficient way to detect fungal development in maize grains? Agric Food 6: 37-51.
  • Bailly S, El Mahgubi A, Carvajal-Campos A, Lorber S, Puel O, Oswald IP, Bailly J-D, Orlando B. 2018. Occurrence and identification of Aspergillus section flavi in the context of the emergence of aflatoxins in french maize. Toxins 10. pii: E525.
  • Caceres I, Snini SP, Puel O, Mathieu F. 2018. Streptomyces roseolus, a promising biocontrol agent against Aspergillus flavus, the main aflatoxin B1 producer. Toxins 10. pii: E442.
  • Da Silva EO, Bracarense APFRL, Oswald IP. 2018. Mycotoxins and oxydative stress: where are we? World Mycotoxin J. 11: 113-134 .
  • El Hajj Assaf C, Snini SP, Tadrist S, Bailly S, Naylies C, Oswald IP, Lorber S, Puel O. 2018. Impact f veA on the development, aggressiveness, dissemination and secondary metabolism of Penicillium expansum. Mol Plant Pathol. 19: 1971-1983.
  • Garcia GR, Payros D, Pinton P, Dogi CA, Laffitte J, Neves M, Gonzalez Pereyra ML, Cavaglieri LR, Oswald IP. 2018. Intestinal toxicity of deoxynivalenol is limited by Lactobacillus rhamnosus RC007 in pig jejunum explants. Arch Toxicol. 92: 883-993.
  • Gratz SW, Currie V. Richardson AJ, Duncan G, Holtrop G, Farquharson F, Louis P, Pinton P, Oswald IP. 2018. Porcine small and large intestinal microbiota rapidly hydrolyze the masked mycotoxin deoxynivalenol-3-glucoside and release deoxynivalenol in vitro. Appl Env Microbiol. 84: e02106-17.
  • Hautbergue T, Jamin EL, Debrauwer L, Puel O, Oswald IP. 2018. From genomics to metabolomics, moving toward an integrated strategy for the discovery of fungal secondary metabolites. Nat Prod Rep. 35: 147-173.
  • Le TH, Alassane-Kpembi I, Pinton P, Oswald IP. 2018. Analysis of the interactions between environmental and food contaminants, cadmium and deoxynivalenol, in different target organs. Sci Tot Environ. 622-623: 841-848.
  • Liber Y., Létondor C., Pascal-Lorber S., Laurent F. 2018. Growth parameters influencing uptake of chlordecone by Miscanthus species. Sci Total Environ. 624C: 831-837.
  • Maruo VM, Bracarense AP, Metayer JP, Vilarino M, Oswald IP, Pinton P. 2018. Ergot Alkaloids at doses close to EU regulatory limits induce alterations of the liver and intestine. Toxins 10. pii: E183.
  • Mateos I, Combes S, Pascal G, Cauquil L, Barillly C, Cossalter AM, Laffitte J, Botti S, Pinton P, Oswald IP. 2018. Fumonisin-exposure impairs age-related ecological succession of bacterial species in weaned pig gut microbiota. Toxins 10. pii: E230.
  • Moore GG, Mack BM, Beltz SB, Puel O. 2018. Genome sequence of an aflatoxigenic pathogen of Argentinian peanut, Aspergillus arachidicola. BMC Genomics 19: 189.
  • Pierron A, Bracarense APFL, Cossalter AM, Laffitte J, Schwartz-Zimmermann, Schatzmayr G, Pinton P, Moll WD, Oswald IP. 2018. Deepoxy-deoxynivalenol retains some immune-modulatory properties of the parent molecule deoxynivalenol in piglets. Arch Toxicol. 92: 3381-3389.
  • Soler L, Oswald IP. The importance of accounting for sex in the search of proteomic signatures of mycotoxin exposure. J Proteomics 178: 114-122.
  • Tannous J, Keller NP, Atoui A, El Khoury A, Lteif R, Oswald IP, Puel O. 2018. Secondary Metabolism in Penicillium expansum: Emphasis on Recent Advances in Patulin Research. Crit. Rev. Food Sci Nutr. 58: 2082-2098.
  • Terciolo C, Maresca M, Pinton P, Oswald IP. 2018. Role of satiety hormones in anorexia induction by trichothecene mycotoxins. Food Chem Toxicol. 121: 701-714.
  • Theumer MG, Henneb Y, Khoury L, Tadrist S, Canler C, Puel O, Oswald IP, Audebert M. 2018. Genotoxicity of aflatoxins and their precursors in human cells. Toxicol Lett. 287: 100-107.


  • Alassane-Kpembi I, Gerez JR, Cossalter AM, Neves M, Laffitte J, Naylies C, Lippi Y, Kolf-Clauw M, Bracarense APL, Pinton P, Oswald IP. 2017. Intestinal toxicity of the type B trichothecene mycotoxin fusarenon-X: whole transcriptome profiling reveals new signaling pathways. Sci Rep. 7: 7530.
  • Alassane-Kpembi I, Puel O, Pinton P, Cossalter AM, Chou TC, Oswald IP. 2017. Co-exposure to low doses of the food contaminants deoxynivalenol and nivalenol has a synergistic inflammatory effect on intestinal explants. Arch Toxicol. 91: 2677-2687.
  • Alassane-Kpembi I, Schatzmayr G, Taranu D, Marin D, Puel O, Oswald IP. 2017. Mycotoxins co-contamination: Methodological aspects and biological relevance of combined toxicity studies. Crit Rev Food Sci Nutr. 57: 3489-3507.
  • Aleksic B, Draghi M, Ritoux S, Bailly S, Lacroix M, Oswald IP, Bailly JD, Robine E. 2017. Aerosolization of mycotoxins after growth of toxinogenic fungi on wallpaper. Appl Environ Microbiol. pii: AEM.01001-17.
  • Bracarense APFL, Basso KM, da Silva EO, Payros D, Oswald IP. 2017. Deoxynivalenol in the liver and lymphoid organs of rats: effects of dose and duration on immunohistological changes. World Mycotoxin J. 10: 89-96.
  • Caceres I, El Khoury R, Bailly S, Oswald IP, Puel O, Bailly JD. 2017. Piperine inhibits aflatoxin B1 production in Aspergillus flavus by modulating fungal oxidative stress response. Fungal Genet. Biol. 107: 77-85.
  • Carvajal-Campos A, Manizan AL, Tadrist S, Koffi Akaki D, Koffi-Nevry R, Moore GG, Fapohunda SO, Bailly S, Montet D, Oswald IP, Lorber S, Brabet C, Puel O. Aspergillus korhogoensis, a novel aflatoxin producing species from the Côte d’Ivoire. Toxins 9. pii: E353.
  • Combes S, Massip K, Martin O, Furbeyre H, Cauquil L, Pascal G, Bouchez O, Le Floch N, Zemb O, Oswald IP, Gidenne T. 2017. Impact of feed restriction and housing hygiene conditions on specific and inflammatory immune response, the cecal bacterial community and the survival of young rabbits. Animal. 11: 854-863.
  • De Pascali SA, Gambacorta L, Oswald IP, Del Coco L, Solfrizzo M, Fanizzi FP. 2017. 1H NMR and MVA metabolomic profiles of urines from piglets fed with boluses contaminated with a mixture of five mycotoxins. Biochem Biophys Rep. 11: 9-18.
  • El Khoury R, Caceres I, Puel O, Bailly S, Atoui A, Oswald IP, El Khoury A, Bailly JD. 2017. Identification of a new anti-aflatoxinogenic aqueous extract from Micromeria graeca and elucidation of its molecular mechanism in Aspergillus flavus. Toxins 9. pii: E87.
  • Hautbergue T, Puel O, Tadrist S, Meneghetti L, Péan M, Delaforge M, Debrauwer L, Oswald IP, Jamin EL. 2017. Evidencing 98 secondary metabolites of Penicillium verrucosum using substrate isotopic labeling and high-resolution mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed Life Sci. 1071: 29-43.
  • Hymery N, Puel O, Tadrist S, Canlet C, Le Scouarnec H, Coton E, Coton M. 2017. Effect of PR toxin on TPH1 and Caco-2 cells: an in vitro study. World Mycotox. 10: 375-386.
  • Myers RR, Smith TD, Elsawa SF, Puel O, Tadrist S, Calvo AM. rtfA controls development, secondary metabolism, and virulence in Aspergillus fumigatus. 2017. PloS One. 12: e0176702.
  • Payros D, Dobrindt U, Martin P, Secher T, Bracarense APFL, Boury M, Laffitte J, Pinton P, Oswald E, Oswald IP. 2017. Food contaminant deoxynivalenol exacerbates the genotoxicity of gut microbiota. mBio. 8: e00007-17.
  • Régnier M, Gourbeyre P, Pinton P, Napper S, Laffitte J, Cossalter AM, Bailly JD, Lippi Y, Bertrand-Michel J, Bracarense APFRL, Guillou H, Loiseau N, Oswald IP. 2017. Identification of Signaling Pathways Targeted by the Food Contaminant FB1: Transcriptome and Kinome Analysis of Samples from Pig Liver and Intestine. Mol Nutr Food Res. 61: 1700433.
  • Robert H, Payros D, Pinton P, Théodorou V, Mercier-Bonin M, Oswald IP. 2017. Mucus and Microbiota as key partners of the intestinal barrier function: new targets for mycotoxins? J Toxicol Env Health, Part B: Crit Rev. 20: 249-275.
  • Souto PCMC, Jager AV, Tonin FG, Petta T, Di Gregorio MC, Cossalter AM, Pinton P, Oswald IP, Rottinghaus GE, Oliveira CAF. 2017. Determination of fumonisin B1 levels in body fluids and hair from piglets fed fumonisin B1-contaminated diets. Food Chem. Toxicol. 108(Pt A):1-9.
  • Tannous J, Snini S, El Khoury R, Canlet C, Pinton P, Lippi Y, Alassane‑Kpembi I, Gauthier T, El Khoury A, Atoui A, Zhou T, Lteif R, Oswald IP, Puel O. 2017. Patulin transformation products and last intermediates in its biosynthetic pathway, E‑ and Z‑ascladiol, are not toxic to human cells. Arch Toxicol. 91: 2455-2467.


  • Alassane-Kpembi I, Oswald IP. 2016. Toxicological interactions between mycotoxins. In Food Contaminants and Human Health: Challenges in chemical mixtures. Edited by P Alvito, R Assunção, H Louro, M João Silva and E Vasco. pp 94-98.
  • Aleksic B, Bailly S, Draghi M, Pestka JJ, Oswald IP, Robine E, Bailly JD, Lacroix MZ. 2016. Production of four macrocyclic trichothecenes by Stachybotrys chartarum during its development on different building materials as measured by UPLC-MS/MS. Build Environ. 106: 265-273.
  • Amuzie C, Bandyopadhyay R, Bhat RV, Black R, Burger H, Cardwell KF, Gelderblom W, Gong YY, Groopman JD, Kimanya M, Miller JD, Oswald I, Pascale M, Payne GA, Phillips TD, Riley R, Shephard GS, Stoltzfus R, Sugita-Konishi Y, Turner PC, Wogan GN, Wu F. 2016. Mycotoxin control in low- and milddle income countries. IARC working group report N°9. Edited by C.P. Wild, J.D. Miller and J.D. Groopman. 54 pp.
  • Caceres I, El Khoury R, Medina A, Lippi Y, Naylies C, Atoui A, El Khoury A, Oswald IP, Bailly JD, Puel O. 2016. Deciphering the anti-aflatoxinogenic properties of eugenol using a large scale qPCR approach. Toxins 8: 123.
  • Cano PM, Puel O, Oswald IP. 2016. Mycotoxins: Fungal Secondary Metabolites with Toxic Properties. In Fungi: Applications and management strategies. Edited by Deshmukh SK, Misra JK, Tewari JP, Papp T: pp 318-371.
  • Cheat S, Oswald IP, Kolf-Clauw M. 2016. Mycotoxin Outbreak in Animal Feed in Foodborne Diseases: Case studies of outbreaks in agri-food industries. Edited by JM Soon, L Manning and C Wallace. pp 257-285.
  • Cheat S, Pinton P, Cossalter AM, Cognié J, Callu P, Vilarano M, Raymond-Letron I, Oswald IP, Kolf-Clauw M. 2016. The mycotoxins deoxynivalnol and nivalenol show in vivo synergism on jejunum enterocytes apoptosis. Food Chem Toxicol. 87: 45-54.
  • Gambacorta L, Pinton P, Avantaggiato G, Oswald IP, Solfrizzo M. 2016. Grape pomace, an agricultural by-product reducing mycotoxins absorption: in vivo assessment in pig using urinary biomarkers. J Agric Food Chem. 64: 6762-6771.
  • Herrera M, Anadon R, Iqbal SZ, Bailly JD, Arino A. 2016. Climate change and food safety. In Food safety, Basic concepts, recent issues and future challenges. Selamat and Iqbal (ed), Springer, pp 149-160.
  • Karlovsky P, Suman M, Berthiller F, De Meester J, Eisenbrand G, Perrin I, Oswald IP, Speijers G, Chiodini A, Recker T, Dussort P. 2016. Impact of food processing and detoxification treatments on mycotoxin contamination. Mycotoxin Res. 32: 179-205.
  • Knudsen C, Combes S, Mousavikhorshidi H, Oswald IP, Gidenne T. 2016. An LPS based method to stimulate the inflammatory response in growing rabbits. World Rabbit J. 24: 55-65.
  • Maidana L, Gerez JR, El Khoury R, Pinho F, Puel O, Oswald IP, Bracarense APFL. 2016. Effect of patulin and ascladiol on intestinal mucosa: an ex vivo approach. Food Chem Toxicol. 98: 189-194.
  • Pascal-Lorber S, Létondor C, Liber Y, Laurent F. 2016. Uptake and distribution of chlordecone in maize shoots. J. Agric. Food Chem. 64: 409-415.
  • Payros D, Alassane-Kpembi I, Pierron A, Loiseau N, Pinton P, Oswald IP. 2016. Toxicology of deoxynivalenol and its acetylated and modified forms. Arch Toxicol. 90: 2931-2957.
  • Pierron A., Alassane-Kpembi I., Oswald IP. 2016. Impact of two mycotoxins Deoxynivalenol and Fumonisin on pig intestinal health. Porcine Health Manag. 2: 21.
  • Pierron A, Alassane-Kpembi I, Oswald IP. 2016. Impact of mycotoxin on immune response and consequences for pig health. Animal Nutr. 2: 63-68.
  • Pierron A, Mimoun S, Murate LS, Loiseau N, Lippi Y, Bracarense APFL, Liaubet L, Schatzmayr G, Berthiller F, Moll WD, Oswald IP. 2016. Intestinal toxicity of the masked mycotoxin deoxynivalenol-3-B-D-glucoside. Arch Toxicol. 90: 2037-2046.
  • Pierron A, Mimoun S, Murate LS, Loiseau N, Lippi Y, Bracarense APFL, Schatzmayr G, He J, Zhou T, Moll WD, Oswald IP. 2016. Microbial biotransformation of DON: molecular basis for reduced toxicity. Sci Rep. 6: 29105.
  • Snini SP, Tannous J, Heuillard P, Bailly S, Lippi Y, Zheraoui E, Barreau C, Oswald IP, Puel O. 2016. The patulin is a cultivar dependant aggressiveness factor favoring the colonization of apples by Penicillium expansum. Mol Plant Pathol. 17: 920-930.
  • Tannous J, Atoui A, El Khoury A, Ziad F, Oswald IP, Puel O, Lteif R. 2016. A study on the physicochemical parameters for Penicillium expansum growth and patulin production: Effect of temperature, pH and water activity. Food Sci Nutr. 4: 611-622.


  • Adjovi YCS, Gnonlonfin BJG, Bailly S, Bailly JD, Tadrist S, Puel O, Oswald IP, Sanni A. 2015. Occurrence of mycotoxins in cassava (Manihot esculenta Crantz) and its products. Int J Food Safety, Nutr Public Health. 5: 217-247.
  • Alassane-Kpembi I, Puel O, Oswald IP. 2015. Toxicological interactions between the mycotoxins deoxynivalenol, nivalenol and their acetyl derivatives in intestinal epithelial cells. Arch. Toxicol. 89: 1337-1346.
  • Herrera M, Anadon R, Iqbal SZ, Bailly JD, Arino A. 2016. Climate change and food safety. In Food safety, Basic concepts, recent issues and future challenges. Selamat and Iqbal (ed), Springer, pp 149-160.
  • Cheat S, Gerez JR, Cognié J, Alassane-Kpembi I, Bracarense APFL, Raymond-Letron I, Oswald IP, Kolf-Clauw M. 2015. Nivalenol has a greater impact than deoxynivalenol on pig jejunum mucosa in vitro on explants and in vivo on intestinal loops. Toxins 7: 1945-1961
  • Fontaine K, Hymery N, Lacroix MZ, Puel S, Puel O, Rigalma K, Gaydou V, Coton E, Mounier J. 2015. Influence of intraspecific variability and abiotic factors on mycotoxin production in Penicillium roqueforti. Int. J. Food Microbiol. 215: 187-193.
  • Gerez JR, Pinton P, Callu P, Grosjean F, Oswald IP, Bracarense APFL. 2015. Deoxynivalenol alone or in combination with nivalenol and zearalenone induce systemic histological changes in pigs. Exp. Toxicicol. Pathol. 67: 89-98.
  • Gourbeyre P, Berri M, Lippi Y, Meurens F, Vincent-Naulleau S, Laffitte J, Rogel-Gaillard C, Pinton P, Oswald IP. 2015. Pattern recognition receptors in the gut: analysis of their expression along the intestinal tract and the crypt/villus axis. Physiol Report 3: e12225.
  • Graziani F, Pujol A, Nicoletti C, Pinton P, Armand L, Di Pasquale E, Oswald IP, Perrier J, Maresca M. 2015. The food-associated ribotoxin deoxynivalenol modulates the expression of the inducible NO synthase by the human intestinal epithelium. Toxicol. Sci. 145: 372–3821.
  • Jacquier V, Estellé J, Panneau B, Lecardonnel J, Moroldo M, Lemonnier G, Turner-Maier J, Duranthon V, Oswald IP, Gidenne T, Rogel-Gaillard C. . 2015. Genome-wide immunity studies in the rabbit: transcriptome variations in PBMCs after in vitro stimulation by LPS or PMA-ionomycin. BMC Genomics. 16: 26.
  • Knudsen C, Combes S, Briens C, Duperray J, Rebours G, Salaun JM, Travel A, Weissman D, Gidenne T, Oswald IP. 2015. Quantitative feed restriction rather than caloric restriction modulates the immune response of the growing rabbit. J. Nutr. 145: 483-9.
  • Levasseur-Garcia C, Bailly S, Kleiber D, Bailly JD. 2015. Assessing Risk of Fumonisin Contamination in Maize Using Near-Infrared Spectroscopy. J. Chem. : Article ID 485864.
  • Loiseau N, Polizzi A, Dupuy A, Therville N, Rakotonirainy M, Loy J, Viadere JL, Cossalter AM, Bailly JD, Puel O, Kolf-Clauw M, Bertrand-Michel J, Levade T, Guillou H, Oswald IP. 2015. New insights in the organ-specific adverse effects of Fumonisin B1: comparison between lung and liver. Arch. Toxicol. 89: 1619-1629.
  • Pinton P, Graziani F, Pujol A, Nicoletti C, Paris O, Ernouf P, Di Pasquale E, Perrier J, Oswald IP, Maresca M. 2015. Deoxynivalenol inhibits the expression by goblet cells of intestinal mucins through a PKR and MAP kinase-dependent repression of the resistin-like molecule β. Mol. Food Nutr. Res. 59: 1076-1087.
  • Tannous J, Atoui A, El Khoury A, Kantar S, Chdid N, Lippi Y, Oswald IP, Puel O, Lteif R. 2015. Development of a Real-Time PCR assay for Penicillium expansum quantification and patulin estimation in apples. Food Microbiol. 50: 28-37.


  • Adjovi YCS, Bailly S, Gnonlonfin BJG, Tadrist S, Querin A, Sanni A, Oswald IP, Puel O, Bailly JD. 2014. Analysis of the contrast between natural occurrence of toxigenic Aspergillus of the flavi section and aflatoxin B1 in cassava. Food Microbiol. 38: 151-159.
  • Cabaret O, Puel O, Botterel F, Delaforge M, Bretagne S. 2014. Metabolic detoxication pathways for methoxy-sterigmatocystin in primary tracheal epithelial cells. Xenobiotica 44: 1-9.
  • Finamore A, Roselli M, Imbinto A, Seeboth J, Oswald IP, Mengheri E. 2014. Lactobacillus amylovorus inhibits the TLR4 inflammatory signaling triggered by enterotoxigenic Escherichia coli via modulation of the negative regulators and involvement of TLR2 in intestinal Caco-2 cells and pig explants. PlosOne 9: e94891.
  • Jacquier V, Combes S, Oswald IP, Rogel-Gaillard C, Gidenne T. 2014. Early modulation of the cecal microbial activity in the young rabbit with rapidly fermentable fiber: impact on health and growth. J. Anim. Sci. 92: 5551-9.
  • Mach N, Berri M, Esquerré D, Lemonnier G, Billon Y, Lepage P, Oswald IP, Doré J, Rogel-Gaillard C, Estellé J. 2014. Extensive expression differences along porcine small intestine evidenced by transcriptome sequencing. PlosOne 9: e88515.
  • Miller JD, Schaafsma AW, Bhatnagar D, Bondy G, Carbone I, Harris L, Harrison G, Munkvold G, Oswald IP, Pestka J, Sharpe L, Sumarah M, Tittlemier S, Zhou T. 2014. Mycotoxins that affect the North American Agri-Food sector: state of the art and directions for the future. World Mycotoxin J. 7: 63-82.
  • Pinton P, Oswald IP. 2014. Effect of doexynivalenol and other type B trichothecenes on the intestine: a review. Toxins 6: 1615-1643.
  • Snini S, Tadrist S, Lafitte J, Jamin EL, Oswald IP, Puel O. 2014. The gene PatG, involved in biosynthesis pathway of patulin, a food-borne mycotoxin, encodes a 6-methylsalicylic acid decarboxylase. Int. J. Food Microbiol. 171: 77-83.
  • Tannous J, El Khoury R, Snini SP, Lippi Y, El Khoury A, Atoui A, Lteiff R, Oswald IP, Puel O. 2014. Sequencing, physical organization and kinetic expression of the patulin biosynthetic gene cluster from Penicillium expansum. Int. J. Food Microbiol. 189: 51-60.


  • Alassane-Kpembi I, Kolf-Clauw M, Gauthier T, Abrami R, Abiola FA, Oswald IP, Puel O. 2013. New insight into mycotoxin mixtures: the toxicity of low doses of Type B trichothecenes against intestinal epithelial cells is synergistic. Tox. Appl. Pharmacol. 272: 191-198.
  • Bekhouche F., Merabti R., Bailly JD. 2013. Traditional couscous manufacture from fermented wheat (Algeria): process and technological and nutritional quality. Afr. J. Sci. Technol. 4: 167-175.
  • Berthiller F, Crews C, Dall'Asta C, De Saeger S, Haesaert G, Karlovsky P, Oswald IP, Seefelder W, Speijers G, Stroka J. 2013. Masked Mycotoxins: A review. Mol. Nutr. Food Res. 57: 165–86.
  • Burel C, Tanguy M, Guerre P, Boilletot E, Cariolet R, Queguiner M, Postollec G, Pinton P, Oswald IP, Fravalo P. 2013. Effect of low dose of fumonisins on pig health: immune status, intestinal microbiota and sensitivity to Salmonella. Toxins 5: 841-864.
  • Cano PM, Jamin EL, Tadrist S, Bourdaudhui P, Péan M, Debrauwer L, Oswald IP, Delaforge M, Puel O. 2013. New untargeted metabolic profiling combining mass spectrometry and isotopic labeling: application on Aspergillus fumigatus grown on wheat. Anal. Chem. 85: 8412-20.
  • Cano P*, Seeboth J*, Meurens F, Cognie J, Abrami R, Oswald IP, Guzylack-Piriou L. 2013. Deoxynivalenol as a new factor in the persistence of intestinal inflammatory diseases : an emerging hypothesis through possible modulation of Th17-mediated response. PlosOne 8: e53647. * Equally contributed
  • El Mahgubi A, Puel O, Bailly S, Tadrist S, Querin A, Ouadia A, Oswald IP , Bailly JD. 2013. Distribution and toxigenicity of Aspergillus section Flavi in spices marketed in Morocco. Food Control 32: 143-8.
  • Gaige S, Bonnet MS, Tardivel C, Pinton P, Trouslard J, Jean A, Guzylack L, Troadec JD, Dallaporta M. 2013. c-Fos immunoreactivity in the Pig brain following deoxynivalenol intoxication: focus on NUCB2/nesfatin-1 expressing neurons. Neurotoxicology 34: 135-49.
  • Gambacorta L, Solfrizzo M, Viconti A, Powers S, Cossalter AM, Pinton P, Oswald IP. 2013. Validation of urinary biomarkers of exposure for aflatoxin B1, ochratoxin A, fumonisin B1, deoxynivalenol and zearalenone in piglets. World Mycotoxin J. 6: 299-30.
  • Gauthier T, Waché Y, Laffitte J, Taranu I, Saeedikouzehkonani N, Mori Y, Oswald IP. 2013. Deoxynivalenol impairs the immune functions of porcine neutrophils. Mol. Nutr. Food Res. 57: 1026-36.
  • Grenier B, Bracarense APFL, Schwartz HE, Lucioli J, Cossalter AM, Moll WD, Schatzmayr G, Oswald IP. 2013. Biotransformation approaches to alleviate the effects induced by Fusarium mycotoxins in swine. J. Agr. Food Chem. 61: 6711-6719.
  • Kolf-Clauw M, Sassahara M, Lucioli J, Rubira-Gerez J, Alassane-Kpembi I, Lyazhri F, Borin C, Oswald IP. 2013. The emerging mycotoxin, enniatin B1, down-modulates the digestive toxicity of T-2-toxin in vitro on intestinal epithelial cells and ex-vivo on intestinal explants. Arch. Toxicol. 87: 2233–2241.
  • Lucioli J, Pinton P, Callu P, Laffitte J, Grosjean F, Kolf-Clauw M, Oswald IP, Bracarense AP. 2013. The food contaminant deoxynivalenol activates the mitogen activated protein kinases in the intestine: comparison of in vivo and ex vivo models. Toxicon 66: 31-6.
  • Mach N, Gao Y, Lemonnier G, Lecardonnel J, Oswald IP, Estellé J, Rogel-Gaillard C. 2013. The peripheral blood transcriptome reflects variations in immunity traits in swine: toward identification of biomarkers. BMC Genomics 14: 894.


  • Bracarense AP, Lucioli J, Grenier B, Drociunas-Pacheco G, Moll WD, Schatzmayr G, Oswald IP. 2012. Chronic ingestion of deoxynivalenol and fumonisin, alone or in interaction, induces morphological and immunological changes in the intestine of piglets. Br. J. Nutr. 107: 1776-86.
  • Gauthier T, Wang X, Dos Santos JS, Fysikopoulos A, Tadrist S, Canlet C, Artigot MP, Loiseau N, Oswald IP, Puel O. 2012. Trypacidin, a spore borne toxin fromAspergillus fumigatus, induces cytotoxicity inlung cells. PLOSone 7: e29906.
  • Grenier B,Bracarense AP, Schwartz HE, Trumel C, Cossalter AM, Schatzmayr G, Kolf-Clauw M, Moll WD, Oswald IP. 2012. The low intestinal and hepatic toxicity of hydrolyzed fumonisin B1 correlates with its inability to alter the metabolism of sphingolipids. Biochem. Pharmacol. 83: 1465-73
  • Hopton R, Oswald IP, Hardie L, Turner P, Fisher J. 2012. Nuclear magnetic resonance analysis of glucose levels in weanling piglets plasma as a function of deoxynivalenol exposure. ISRN Anal Chem: Article ID 132543.
  • Jakšić D, Puel O, Canlet C, Kopjar N, Kosalec I, Klarić M. 2012. Cytotoxicity and genotoxicity of versicolorins and 5-methoxysterigmatocystin in A549 cells. Arch. Toxicol. 84: 641-50.
  • Mickiewicz M, Zabielski R, Grenier B, Le Normand L, Savary G, Holst JJ, Oswald IP, Metges CC, Guilloteau PP. 2012. Structural and functional development of small intestine in intrauterine growth retarded porcine offspring born to gilts fed diets with differing protein ratios throughout pregnancy. J. Physiol. Pharmacol. 63: 225-39.
  • Pacheco GD, Silva CA, Pinton P, Oswald IP, Bracarense AP. 2012. Phytic acid protects porcine intestinal epithelial cells from deoxynivalenol (DON) cytotoxicity. Exp. Toxicol. Pathol. 64: 345-7.
  • Pinton P, Guzylack-Piriou L, Kolf-Clauw M, Oswald IP. 2012. Effects of some fungal toxins, the trichothecenes, on the intestine. Curr. Immunol. Rev. 8: 193-208.
  • Pinton P, Tsybulskyy D, Lucioli J, Laffitte J, Callu P, Lyazhri F, Grosjean F, Bracarense AP, Kolf-Clauw M, Oswald IP. 2012. Toxicity of deoxynivalenol and its acetylated derivatives on the intestine: differential effects on morphology, barrier function, tight junctions proteins and MAPKinases. Tox. Sci. 130: 180-90.
  • Seeboth J, Solinhac R, Oswald IP, Guzylack-Piriou L. 2012. The fungal T-2 toxin alters the activation of primary macrophages induced by TLR-agonists resulting in a decrease of the inflammatory response in pigs. Vet. Res. 43: 35.
  • Siddique MH, Liboz T, Bacha N, Puel O, Mathieu F, Lebrihi A. 2012. Characterization of a cytochrome P450 monooxygenase gene involved in the biosynthesis of geosmin in Penicillium expansum. Afr. J. Microbiol. Res. 6: 4122-27.
  • Streit E, Schatzmayr G,Tassis P, Tzika E, Marin D, Taranu I, Tabuc C, Nicolau A, Aprodu I, Puel O, Oswald IP. 2012. Current Situation of Mycotoxin Contamination and Co-occurrence in Animal Feed - Focus on Europe. Toxins 4: 788-809.



  • Arnich N, Canivenc-Lavier C, Kolf-Clauw M, Coffigny H, Cravedi JP, Grob K, Macherey MC, Masset D, Maximilien R, Narbonne JF, Nesslany F, Stadler J, Tulliez J. 2011. Conclusions of the French Food Safety Agency on the toxicity of Bisphenol A. Int. J. Hyg. Environ. Health 214: 271-275.
  • Cabaret O, Puel O, Botterel F, Pean M, Bretagne S, Delaforge M. 2011. Contribution of uniformly 13C-enriched sterigmatocystin to the study of its pulmonary metabolism. Rapid. Comm. Mass Spectro. 25: 2704-10.
  • Fiebach AR, Guzylack-Piriou L, Python S, Summerfield A, Ruggli N. 2011. Classical Swine Fever virus npro limits type I interferon induction in plasmacytoid dendritic cells by interacting with interferon regulatory factor 7. J. Virol. 85: 8002-11.
  • Flori L, Gao Y, Oswald IP, Lefevre F, Bouffaud M, Mercat MJ, Bidanel JP, Rogel-Gaillard C. 2011. Deciphering the genetic control of innate and adaptive immune responses in pig: a combined genetic and genomic study. BMC Proceedings 5(Suppl 4): S32.
  • Flori L, Gao Y, Laloe D, Lemonier G, Teillaud A, Cossalter AM, Laffitte J, Pinton P, de Vaureix C, Bouffaud M, Mercat MJ, Lefevre F, Oswald IP, Bidanel JP, Rogel-Gaillard C. 2011. Immunity traits in pigs: substantial genetic variation and limited covariation. Plos One 6: e22717.
  • Grenier B, Loureiro-Bracarense AP, Lucioli J, Drociunas-Pacheco G, Cossalter AM, Moll WD, Schatzmayr G, Oswald IP. 2011. Individual and combined effects of subclinical doses of deoxynivalenol and fumonisins in piglets. Mol. Nutr. Food Res. 55: 761-71.
  • Grenier B, Oswald IP. 2011. Mycotoxin co-contamination of foods and feeds: meta-analysis of publications describing toxicological interactions. World Mycotoxin J. 4: 285-313.
  • Moulin HR, Liniger M, Python S, Guzylack-Piriou L, Ocaña-Macchi M, Ruggli N, Summerfield A. 2011. High interferon type I responses in the lung, plasma and spleen during highly pathogenic H5N1 infection of chicken. Vet. Res. 42: 6.
  • Trandaburu I, Oswald IP, Trandaburu T. 2011. The  immunohistochemical localization of the glycosphingolipid asialo-GM1 in the intestine of weaned piglets. Acta Histochemica 113: 103-8.



  • Cabaret O, Puel O, Botterel F, Pean M, Khoufache K, Costa JM, Delaforge M, Bretagne S. 2010. Metabolic detoxication pathways for sterigmatocystin in primary tracheal epithelial cells. Chem. Res. Toxicol. 23: 1673-81
  • Gao Y, Flori L. Lecardonnel J, Esquerre D, Hu Z, Teillaud A, Lemonier G, Lefevre F, Oswald IP,Rogel-Gaillard C. 2010. Transcritome analysis of porcine PBMC after stimulation by LPS or PMA/ionomycin using an expression array targeting the pig immune response. BMC genomics 11: 292.
  • Guzylack-Piriou L, Alves MP, Mccullough KC, Summerfield A. 2010. Porcine Flt3 ligand and its receptor: Generation of dendritic cells and identification of a new marker for porcine dendritic cells. Dev. Comp. Immunol. 34: 455-64.
  • Lallès JP, Lessard M, Oswald IP, David JC. 2010. Consumption of fumonisin B1 for 9 days induces stress proteins along the gastrointestinal tract of pigs. Toxicon 55: 244–9.
  • Pinton P, Braicu C, Nougayrede JP, Laffitte J, Taranu I, Oswald IP. 2010. Deoxynivalenol impairs porcine intestinal barrier function and decreases the protein expression of claudin-4 through a Mitogen Activated Protein kinase dependant mechanism. J. Nutr. 140: 1956–62.
  •  Puel O, Galtier P, Oswald IP. 2010. Biosynthesis and toxicological effects of patulin. Toxins 2: 613-631.


  • Artigot MP, Loiseau N, Laffitte J, Mas-Reguieg L, Tadrist S, Oswald IP, Puel O. 2009. Molecular cloning and functional characterization of two cytochromes P450 CYP619 involved in biosynthesis of patulin in Aspergillus clavatus. Microbiology 155: 1738-1747.
  • Dao HP, Atoui A, Mathieu F, Callaghan JO, Puel O, Liboz T, Dobson ADW, Lebrihi A. 2009. Cloning and characterization of novel methylsalicylic acid synthase gene involved in the biosynthesis of isoasperlactone and asperlactone in Aspergillus westerdijkiae. Fungal Genet. Biol. 46, 742-749.
  • Devriendt B*, Gallois M*, Verdonck F, Wache Y, Bimzok D, Oswald IP, Goddeeris BM, Cox E. 2009. The food contaminant fumonisin B1 reduces maturation of porcine CD11R1+ intestinal antigen presenting cells and antigen-specific immune responses, leading to a prolonged intestinal ETEC infection. Vet. Res. 40: 40.  * Equally contributed
  • Gallois M, Rothkötter HJ, Bailey M, Stokes CR and Oswald IP. 2009. Natural alternatives to in-feed antibiotics in pig production: Can immunomodulators play a role? Animal 3: 1644-1661.
  • Kolf-Clauw M, Castellote J, Joly B, Bourges-Abella N, Raymond I, Pinton P, Oswald IP. 2009. Development of a pig jejunal explant culture for studying the gastrointestinal toxicity of the mycotoxin DON: histopathological analysis. Toxicol. in vitro 23: 1580-84.
  • Le Gall M, Gallois M, Sève B, Holst JJ, Oswald IP, Lallès JP, Guilloteau P. 2009. Comparative effect of sodium butyrate administrated before or after weaning on growth and several indices of gastrointestinal biology of piglets. Br. J. Nutr. 102: 1285-96.
  • Lessard M, Boudry G, Sève B, Oswald IP, Lallès JP. 2009. Intestinal physiology and peptidase activity in male pigs are modulated by consumption of corn culture extracts containing fumonisins. J. Nutr. 139: 1303-1307.
  • Meissonnier GM, Raymond I, Laffite J, Cossalter AM, Pinton P, Benoit E, Bertin G, Galtier P, Oswald IP. 2009. Dietary glucomannan improves the vaccinal response in pigs exposed to AFB1 or T-2 toxin. World Mycotoxin J. 2: 161-172.
  • Pinton P, Nougayrede JP, del Rio JC, Moreno C, Marin D, Ferrier L, Bracarense AP, Kolf-Clauw M, Oswald IP. 2009. The food contaminant, deoxynivalenol, decreases intestinal barrier function and reduces claudin expression. Tox. Appl. Pharmacol. 237: 41-8.
  • Reyns T, De Boever S, Schauvliege S, Gasthuys F, Meissonnier GM, Oswald IP, Croubels S, De Backer P. 2009. Influence of administration route on the biotransformation of amoxicillin in the pig. J. Vet. Pharmacol. Ther. 32: 241-248.
  • Ruggli N, Summerfield A, Fiebach AR, Guzylack-Piriou L, Bauhofer O, Lamm CG, Waltersperger S, Matsuno K, Liu L, Gerber M, Choi KH, Hofmann MA, Sakoda Y, Tratschin JD. 2009. Classical swine fever virus can remain virulent after specific elimination of the interferon regulatory factor 3-degrading function of Npro. J. Virol. 83: 817-29.
  • Waché YJ, Valat C, Bougeard S, Burel C, Oswald IP, Fravalo P. 2009. Impact of Deoxynivalenol on the intestinal microflora of pigs. Int. J. Mol. Sci. 10: 1-17.


  • Bravin F, Duca RC, Loiseau N, Pean M, Puel O, Delaforge M. 2008. Production and use of mycotoxins uniformly enriched with stable isotopes for their dosage in biological samples, World Mycotoxin J. 1: 275-282.
  • Kosalec I, Puel O, Delaforge M, Kopjar N, Antolovi R, Jeli D, Marica B, Galtier P and Pepeljnjak S. 2008. Isolation and cytotoxicity of low-molecular-weight metabolites of Candida albicans. Front. Biosci. 13: 6893-904.
  • Meissonnier GM, Laffitte J, Raymond I, Benoit E, Cossalter AM, Pinton P, Bertin G, Oswald IP, Galtier P. 2008. Subclinical doses of T-2 toxin impair acquired immune response and liver cytochrome P450 in pigs. Toxicology 247: 46-54.
  • Meissonnier GM, Pinton P, Laffitte J, Cossalter AM, Gong YY, Wild CP, Berlin G, Galtier P, Oswald IP. 2008. Immunotoxicity of aflatoxin B1: impairment of the cell-mediated response to vaccine antigen and modulation of cytokine expression. Toxicol. Appl. Pharmacol. 231: 142-149.
  • Pinton P, Accensi F, Beauchamp E, Cossalter AM, Callu P, Grosjean F, Oswald IP. 2008. Ingestion of Deoxynivalenol (DON) contaminated feed alters the pig vaccinal immune responses. Toxicol. Lett. 177: 215-222.


  • Bouhet S and Oswald IP. 2007. The intestine as a possible target for fumonisin toxicity. Mol. Nutr. Food Res. 51: 925-931.
  • Cantiello M, Carletti M, Cannizzo FT, Nebbia C, Bellino C, Pie S, Oswald IP, Bollo E, Dacasto M. 2007. Effects of an illicit cocktail on serum immunoglobulins, lymphocyte proliferation and cytokine gene expression in the veal calf. Toxicology 242: 39-51.
  • Comera C, Andre K, Laffitte J, Collet X, Galtier P, Maridonneau-Parini I. 2007. Gliotoxin from Aspergillus fumigatus affects phagocytosis and the organization of the actin cytoskeleton by distinct signalling pathways in human neutrophils. Microbes Infect. 9: 47-54.
  • Gouze ME, Laffitte J, Pinton P, Dedieux G, Galinier A, Thouvenot JP, Loiseau N, Oswald IP, Galtier P. 2007. Effect of subacute oral doses of nivalenol on immune and metabolic defense systems in mice. Vet. Res. 38: 635-646.
  • Khoufache K*, Puel O*, Loiseau N, Delaforge M, Rivollet D, Coste A, Cordonnier C, Escudier E, Botterel F, Bretagne S. 2007. Verruculogen associated with Aspergillus fumigatus hyphae and conidia modifies the electrophysiological properties of human nasal epithelial cells. BMC Microbiol. 7: 5. * Equally contributed
  • Loiseau N, Debrauwer L, Sambou T, Bouhet S, Miller JD, Martin PG, Viadere JL, Pinton P, Puel O, Pineau T, Tulliez J, Galtier P, Oswald IP. 2007. Fumonisin B1 exposure and its selective effect on porcine jejunal segment: Sphingolipids, glycolipids and trans-epithelial passage disturbance. Biochem. Pharmacol. 74: 144-152.
  • Marin DE, Gouze ME, Taranu I, Oswald IP. 2007. Fumonisin B1 alters cell cycle progression and interleukin-2 synthesis in swine peripheral blood mononuclear cells. Mol. Nutr. Food Res. 51: 1406-1412.
  • Meissonnier GM, Laffitte J, Loiseau N, Benoit E, Raymond I, Pinton P, Cossalter AM, Bertin G, Oswald IP, Galtier P. 2007. Selective impairment of drug-metabolizing enzymes in pig liver during subchronic dietary exposure to aflatoxin B1. Food Chem. Toxicol. 45: 2145-2154.
  • Picherot M, Oswald IP, Cote M, Noeckler K, Le Guerhier F, Boireau P, Vallée I. 2007. Swine infection with Trichinella spiralis: Comparative analysis of the mucosal intestinal and systemic immune responses. Vet. Parasitol. 143: 122-130.
  • Pie S, Awati A, Vida S, Falluel I, Williams BA, Oswald IP. 2007. Effects of added fermentable carbohydrates in the diet on intestinal pro-inflammatory cytokine expression in weaning piglets. J. Anim. Sci. 85: 673-683.
  • Puel O, Tadrist S, Delaforge M, Oswald IP, Lebrihi A. 2007. The inability of Byssochlamys fulva to produce patulin is related to absence of 6-methylsalicylic acid synthase and isoepoxydon dehydrogenase genes. Int. J. Food Microbiol. 115: 131-139.
  • Techau ME, Johansen MV, Aasted B, Lind P, Ornbjerg N, Oswald IP. 2007. Cytokine mRNA profiles in pigs exposed prenatally and postnatally to Schistosoma japonicum. Vet. Res. 38: 25-36.


  • Accensi F, Pinton P, Callu P, Abella-Bourges N, Guelfi JF, Grosjean F, Oswald IP. 2006. Ingestion of low doses of deoxynivalenol does not affect hematological, biochemical, or immune responses of piglets. J. Anim. Sci. 84: 1935-1942.
  • Bouhet S, Le Dorze E, Peres S, Fairbrother JM, Oswald IP. 2006. Mycotoxin fumonisin B-1 selectively down-regulates the basal IL-8 expression in pig intestine: in vivo and in vitro studies. Food Chem. Toxicol. 44: 1768-1773.
  • Gouze ME, Laffitte J, Rouimi P, Loiseau N, Oswald IP, Galtier P. 2006. Effect of various doses of deoxynivalenol on liver xenobiotic metabolizing enzymes in mice. Food Chem. Toxicol. 44: 476-483.
  • Marin DE, Taranu I, Bouhet S, Oswald IP. 2006. Effects of a food contaminant, the mycotoxin fumonisin B1, on cytokine production: implication for the immune response to vaccination. Curr. Trends Immunol. 7: 137-43.
  • Marin DE, Taranu I, Pascale F, Lionide A, Burlacu R, Bailly JD, Oswald IP. 2006. Sex-related differences in the immune response of weanling piglets exposed to low doses of fumonisin extract. Br. J. Nutr. 95: 1185-11923.
  • Oswald IP. 2006. Role of intestinal epithelial cells in the innate immune defence of the pig intestine. Vet. Res. 37: 359-368.


  • Bouhet S, Oswald IP. 2005. The effects of mycotoxins, fungal food contaminants, on the intestinal epithelial cell-derived innate immune response. Vet. Immunol. Immunopathol. 108: 199-209.
  • Dacasto M, Eeckhoutte C, Capolonga F, Dupuy J, Carletti M, Calléja C, Nebbia C, Alvinerie M, Galtier P. 2005. Effect of breed and gender on bovine liver cytochrome P450 3A (CYP3A) expression and inter-species comparison with other domestic ruminants. Vet. Res. 36: 179-90.
  • Girard F, Oswald IP, Taranu I, Helie P, Appleyard GD, Harel J, Fairbrother JM. 2005. Host immune status influences the development of attaching and effacing lesions in weaned pigs. Infect. Immun. 73: 5514-5523.
  • Gouze ME, Laffitte J, Dedieu G, Galinier A, Thouvenot JP, Oswald IP, Galtier P. 2005. Individual and combined effects of low oral doses of deoxynivalenol and nivalenol in mice. Cell Mol. Biol. 51: OL809-OL817.
  • Halloy DJ, Gustin PG, Bouhet S, Oswald IP. 2005. Oral exposure to culture material extract containing fumonisins predisposes swine to the development of pneumonitis caused by Pasteurella multocida. Toxicology 213: 34-44.
  • Oswald IP, Marin DE, Bouhet S, Pinton P, Taranu I, Accensi F. 2005. Immunotoxicological risk of mycotoxins for domestic animals. Food Add. Contam. 22: 354-360.
  • Puel O, Tadrist S, Galtier P, Oswald IP, Delaforge M. 2005. Byssochlamys nivea as a source of mycophenolic acid. Appl. Environ. Microbiol. 71: 550-553.
  • Roselli M, Finamore A, Britti MS, Bosi P, Oswald I, Mengheri E. 2005. Alternatives to in-feed antibiotics in pigs: Evaluation of probiotics, zinc or organic acids as protective agents for the intestinal mucosa. A comparison of in vitro and in vivo results. Anim. Res. 54: 203-218.
  • Taranu I, Marin DE, Bouhet S, Pascale F, Bailly JD, Miller JD, Pinton P, Oswald IP. 2005. Mycotoxin fumonisin B-1 alters the cytokine profile and decreases the vaccinal antibody titer in pigs. Toxicol. Sci. 84: 301-307.


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Modification date : 26 January 2024 | Publication date : 16 July 2010 | Redactor : MJA