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  • Bischoff NS, de Kok TM, Sijm DTHM, van Breda SG, Briedé JJ, Castenmiller JJM, Opperhuizen A, Chirino YI, Dirven H, Gott D, Houdeau E, Oomen AG, Poulsen M, Rogler G, van Loveren H. Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System. Int. J. Mol. Sci. 2021, 22(1), 207;


  • Guillard A, Gaultier E, Cartier C, Devoille L, Noireaux J, Chevalier L, Morin M, Grandin F, Lacroix MZ, Coméra C, Cazanave A, de Place A, Gayrard V, Bach V, Chardon K, Bekhti N, Adel-Patient K, Vayssière C, Fisicaro P, Feltin N, de la Farge F, Picard-Hagen N, Lamas B, Houdeau E. Basal Ti level in the human placenta and meconium and evidence of a materno-foetal transfer of food-grade TiO2 nanoparticles in an ex vivo placental perfusion model. Part Fibre Toxicol. 2020 Oct 7;17(1):51. doi: 10.1186/s12989-020-00381-z.
  • Coméra C, Cartier C, Gaultier E, Catrice O, Panouillé Q, El Hamdi S, Tirez K, Nelissen I, Théodorou V, Houdeau E. Jejunal villus absorption and paracellular tight junction permeability are major routes for early intestinal uptake of food-grade TiO2 particles: an in vivo and ex vivo study in mice. Part Fibre Toxicol. 2020 Jun 11; 17(1):26 ; doi: 10.1186/s12989-020-00357-z.
  • Lamas B, Martins Breyner N, Houdeau E. Impacts of foodborne inorganic nanoparticles on the gut microbiota-immune axis: potential consequences for host health. Part Fibre Toxicol. 2020 Jun 1;17(1):19. doi: 10.1186/s12989-020-00349-z. PMID: 32487227; PMCID: PMC7268708.


  • Houdeau E, Lamas B. Nanoparticules dans l’alimentation - Interactions avec le microbiote intestinal, impacts sur la fonction barrière de l’intestin et devenir systémique. Innovations Agronomiques 2019; 73:81-90 [In French]
  • Dorier M, Béal D, Tisseyre C, Marie-Desvergne C, Dubosson M, Barreau F, Houdeau E, Herlin-Boime N, Rabilloud T, Carriere M. The food additive E171 and titanium dioxide nanoparticles indirectly alter the homeostasis of human intestinal epithelial cells in vitro. Environ Sci-Nano 2019; doi: 10.1039/C8EN01188


  • Nygaard UC, Vege Å, Rognum T, Grob K, Cartier C, Cravedi JP, Alexander J. Toxic effects of mineral oil saturated hydrocarbons (MOSH) and relation to accumulation in rat liver. Food Chem Toxicol. 2018 ; 123:431-442. doi: 10.1016/j.fct.2018.11.022.
  • Houdeau E, Lamas B, Lison D, Pierre F. Nanoparticles and food: an emerging risk for human health? Cahiers de Nutrition et de Dietetique. 2018 ; 53:312-321. [in French - Summary in English] Doi : 10.1016/j.cnd.2018.09.001 /
  • Riba A, Olier M, Lacroix-Lamandé S, Lencina C, Bacquié V, Harkat C, Van Langendonck N, Gillet M, Cartier C, Baron M, Sommer C, Mallet V, Zill M, Robert H, Laurent F, Ellero-Simatos S, Theodorou V, Ménard S. Early life stress in mice is a suitable model for Irritable Bowel Syndrome but does not predispose to colitis nor increase susceptibility to enteric infections. Brain Behav Immun. 2018 ; 73:403-415
  • Talbot P, Radziwill-Bienkowska JM, Kamphuis JBJ, Steenkeste K, Bettini S, Robert V, Noordine ML, Mayeur C, Gaultier E, Langella P, Robbe-Masselot C, Houdeau E, Thomas M, Mercier-Bonin M. Food-grade TiO2 is trapped by intestinal mucus in vitro but does not impair mucin O-glycosylation and short-chain fatty acid synthesis in vivo: implications for gut barrier protection. J Nanobiotechnology. 2018 ; 16:53.
  • Radziwill-Bienkowska JM, Talbot P, Kamphuis JBJ, Robert V, Cartier C, Fourquaux I, Lentzen E, Audinot JN, Jamme F, Réfrégiers M, Bardowski JK, Langella P, Kowalczyk M, Houdeau E, Thomas M, Mercier-Bonin M. Toxicity of Food-Grade TiO2 to Commensal Intestinal and Transient Food-Borne Bacteria: New Insights Using Nano-SIMS and Synchrotron UV Fluorescence Imaging. Front Microbiol. 2018 ; 9:794
  • Malaisé Y, Ménard S, Cartier C, Lencina C, Sommer C, Gaultier E, Houdeau E, Guzylack-Piriou L. Consequences of bisphenol a perinatal exposure on immune responses and gut barrier function in mice. Arch Toxicol. 2018 ; 92:347-358.
  • Mercier-Bonin M, Despax B, Raynaud P, Houdeau E, Thomas M. Mucus and microbiota as emerging players in gut nanotoxicology: The example of dietary silver and titanium dioxide nanoparticles. Crit Rev Food Sci Nutr. 2018 ; 14:1-10. [Review].


  • Lamas B [post-doctoral stage], Michel ML, Waldschmitt N, Pham HP, Zacharioudaki V, Dupraz L, Delacre M, Natividad JM, Da Costa G, Planchais J, Sovran B, Bridonneau C, Six A, Langella P, Richard ML, Chamaillard M, Sokol H. CARD9 mediates susceptibility to intestinal pathogens through microbiota modulation and control of bacterial virulence. Gut. 2017 [Published Online First: 08 August 2017]. doi: 10.1136/gutjnl-2017-314195.
  • Bettini S, Boutet-Robinet E, Cartier C, Coméra C, Gaultier E, Dupuy J, Naud N, Taché S, Grysan P, Reguer S, Thieriet N, Réfrégiers M, Thiaudière D, Cravedi JP, Carrière M, Audinot JN, Pierre FH, Guzylack-Piriou L, Houdeau E. Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon. Sci Rep. 2017 ; 7:40373.
  • Malaisé Y, Menard S, Cartier C, Gaultier E, Lasserre F, Lencina C, Harkat C, Geoffre N, Lakhal L, Castan I, Olier M, Houdeau E, Guzylack-Piriou L. Gut dysbiosis and impairment of immune system homeostasis in perinatally-exposed mice to Bisphenol A precede obese phenotype development. Sci Rep. 2017 ; 7:14472
  • Lamas B [post-doctoral stage], Richard ML, Sokol H. Caspase recruitment domain 9, microbiota and tryptophan metabolism: dangerous liaisons in Inflammatory bowel diseases. Lamas B, Richard ML, Sokol H. Curr Opin Clin Nutr Metab Care. 2017 ; 20:243-247.
  • Riba A, Olier M, Lacroix-Lamandé S, Lencina C, Bacquié V, Harkat C, Gillet M, Baron M, Sommer C, Mallet V, Salvador-Cartier C, Laurent F, Théodorou V, Ménard S. Paneth Cell Defects Induce Microbiota Dysbiosis in Mice and Promote Visceral Hypersensitivity. Gastroenterology. 2017 ; 153:1594-1606.e2.
  • Dorier M, Béal D, Marie-Desvergne C, Dubosson M, Barreau F, Houdeau E, Herlin-Boime N, Carrière M. Continuous in vitro exposure of intestinal epithelial cells to E171 food additive causes oxidative stress, inducing oxidation of DNA bases but no endoplasmic reticulum stress. Nanotoxicology. 2017 ;11:751-761.


  • Lamas B[post-doctoral stage], Richard ML, Leducq V, Pham HP, Michel ML, Da Costa G, Bridonneau C, Jegou S, Hoffmann TW, Natividad JM, Brot L, Taleb S, Couturier-Maillard A, Nion-Larmurier I, Merabtene F, Seksik P, Bourrier A, Cosnes J, Ryffel B, Beaugerie L, Launay JM, Langella P, Xavier RJ, Sokol H. CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands. Nat Med. 2016 ; 22:598-605.
  • Mercier-Bonin M, Despax B, Raynaud P, Houdeau E, Thomas M. Mucus and microbiota as emerging players in gut nanotoxicology: The example of dietary silver and titanium dioxide nanoparticles. Crit Rev Food Sci Nutr. 2016 ; 14:1-10. Review.
  • Hessel EV, Ezendam J, van Broekhuizen FA, Hakkert B, DeWitt J, Granum B, Guzylack L, Lawrence BP, Penninks A, Rooney AA, Piersma AH, van Loveren H. Assessment of recent developmental immunotoxicity studies with bisphenol A in the context of the 2015 EFSA t-TDI. Reprod Toxicol. 2016 ; 65:448-456.
  • Houdeau E. Sex differences in gastrointestinal physiology and diseases : from endogenous sex hormones to environmental endocrine disruptor agents. Neigh G, Mitzelfelt M (Eds). In: Sex Differences in Physiology. Elsevier. 2016 ; pp125-143. Book chapter.
  • Guzylack-Piriou L, Malaisé Y, Cartier C, Lencina C, Sommer C, Gaultier E, Houdeau E, Ménard S. Dysregulation of intestinal and systemic immune responses in adults after perinatal exposure to bisphenol A (BPA): Possible involvement of adverse food reactions. Revue Française d’Allergologie. 2016 ; 56:135-136


  • Da Silva S, Robbe-Masselot C, Raymond A, Mercade-Loubière M, Salvador-Cartier C, Ringot B, Léonard R, Fourquaux I, Ait-Belgnaoui A, Loubière P, Theodorou V, Mercier-Bonin M. Spatial Localization and Binding of the Probiotic Lactobacillus farciminis to the Rat Intestinal Mucosa: Influence of Chronic Stress. PLoS One. 2015 ;10:e0136048
  • Guéraud F, Taché S, Steghens JP, Milkovic L, Borovic-Sunjic S, Zarkovic N, Gaultier E, Naud N, Héliès-Toussaint C, Pierre F, Priymenko N. Dietary polyunsaturated fatty acids and heme iron induce oxidative stress biomarkers and a cancer promoting environment in the colon of rats. Free Radic Biol Med. 2015 ; 83:192-200.


  • Menard S, Guzylack-Piriou L, Leveque M, Braniste V, Lencina C, Naturel M, Moussa L, Sekkal S, Harkat C, Gaultier E, Theodorou V, Houdeau E. Food intolerance at adulthood after perinatal exposure to the endocrine disruptor bisphenol A. FASEB J. 2014 ; 28:4893-900.
  • Bettini S, Houdeau E. Oral exposure to titanium dioxide (TiO₂) nanoparticles: from translocation through oral and intestinal epithelia to fate and effects in the organism. Biol Aujourdhui. 2014 ; 208:167-75. Review.
  • Ménard S, Guzylack-Piriou L, Lencina C, Leveque M, Naturel M, Sekkal S, Harkat C, Gaultier E, Olier M, Garcia-Villar R, Theodorou V, Houdeau E. Perinatal exposure to a low dose of bisphenol A impaired systemic cellular immune response and predisposes young rats to intestinal parasitic infection. PLoS One. 2014 ; 9:e112752.
  • Da Silva S, Robbe-Masselot C, Ait-Belgnaoui A, Mancuso A, Mercade-Loubière M, Salvador-Cartier C, Gillet M, Ferrier L, Loubière P, Dague E, Theodorou V, Mercier-Bonin M. Stress disrupts intestinal mucus barrier in rats via mucin O-glycosylation shift: prevention by a probiotic treatment. Am J Physiol Gastrointest Liver Physiol. 2014 ; 307:G420-9.
  • Nébot-Vivinus M, Harkat C, Bzioueche H, Cartier C, Plichon-Dainese R, Moussa L, Eutamene H, Pishvaie D, Holowacz S, Seyrig C, Piche T, Theodorou V. Multispecies probiotic protects gut barrier function in experimental models. World J Gastroenterol. 2014 ; 20:6832-43.
  • Payros D, Secher T, Boury M, Brehin C, Ménard S, Salvador-Cartier C, Cuevas-Ramos G, Watrin C, Marcq I, Nougayrède JP, Dubois D, Bedu A, Garnier F, Clermont O, Denamur E, Plaisancié P, Theodorou V, Fioramonti J, Olier M, Oswald E. Maternally acquired genotoxic Escherichia coli alters offspring's intestinal homeostasis. Gut Microbes. 2014 ; 5:313-25.
  • Ait-Belgnaoui A, Colom A, Braniste V, Ramalho L, Marrot A, Cartier C, Houdeau E, Theodorou V, Tompkins T. Probiotic gut effect prevents the chronic psychological stress-induced brain activity abnormality in mice. Neurogastroenterol Motil. 2014 ; 26:510-20.
  • Moussaoui N, Braniste V, Ait-Belgnaoui A, Gabanou M, Sekkal S, Olier M, Theodorou V, Martin PG, Houdeau E. Changes in intestinal glucocorticoid sensitivity in early life shape the risk of epithelial barrier defect in maternal-deprived rats. PLoS One. 2014 ; 9:e88382.



  • Moussa L, Bézirard V, Salvador-Cartier C, Bacquié V, Houdeau E, Theodorou V. A new soy germ fermented ingredient displays estrogenic and protease inhibitor activities able to prevent irritable bowel syndrome-like symptoms in stressed female rats. Clin Nutr 2013 ; 32:51-8.
  • Gaigé S, Bonnet M, Tardivel C, Pinton P, Trouslard J, Jean A, Guzylack-Piriou L, Troadec J-D, Dallaporta M. C-Fos immunoreactivity in the pig brain following deoxynivalenol intoxication: focus on NUCB2/nesfatin-1 expressing neurons. Toxicology 2013 ; 34:135-49.



  • Moussa L, Bézirard V, Salvador-Cartier C, Bacquié V, Lencina C, Lévêque M, Braniste V, Ménard S, Theodorou V, Houdeau E. A low dose of fermented soy germ alleviates gut barrier injury, hyperalgesia and faecal protease activity in a rat model of inflammatory bowel disease. PLoS One 2012 ; 7:e49547.
  • Braniste V, Houdeau E. Gut: a new target for endocrine disruptors. Cahiers de Nutrition et de Diététique 2012 ; 47:193-200.
  • Houdeau E. Nanoparticules et barrière intestinale: comprendre les mécanismes de franchissement. Innovations Agronomiques 2012 ; 24:105-112.
  • Ait-Belgnaoui A, Durand H, Cartier C, Chaumaz G, Eutamene H, Ferrier L, Houdeau E, Fioramonti J, Bueno L, Theodorou V. Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats. Psychoneuroendocrinology 2012 ; 37:1885-95.



  • Braniste V, Audebert M, Zalko D, Houdeau E. Bisphenol A in the Gut: Another Break in the Wall? In Multi-System Endocrine Disruption - Series: Research and Perspectives in Endocrine Interactions. Bourguignon J-P, Jégou B, Kerdelhué B, Toppari J, Christen Y (Eds). Springer-Verlag Berlin Heidelberg 2011, pp127.
  • Houdeau E. Endocrine disruptors and oral contamination: the forgotten gut. Médecine & Longévité 2011 ; 3:85-93.



  • Braniste V, Jouault A, Gaultier E, Polizzi A, Buisson-Brenac C, Leveque M, Martin PG, Theodorou V, Fioramonti J, Houdeau E. Impact of oral bisphenol A at reference doses on intestinal barrier function and sex differences after perinatal exposure in rats. Proc Natl Acad Sci USA 2010 ; 107:448-53.
  • Agostini S, Eutamene H, Cartier C, Broccardo M, Improta G, Houdeau E, Petrella C, Ferrier L, Theodorou V, Bueno L. Evidence of Central and Peripheral Sensitization in a Rat Model of Narcotic Bowel Like-Syndrome. Gastroenterology 2010 ; 139:553-63.



  • Braniste V, Leveque M, Buisson-Brenac C, Bueno L, Fioramonti J, Houdeau E. Oestradiol decreases colonic permeability through oestrogen receptor beta-mediated up-regulation of occludin and junctional adhesion molecule-A in epithelial cells. J Physiol 2009 ; 587(Pt 13):3317-28.
  • Ait-Belgnaoui A, Eutamene H, Houdeau E, Bueno L, Fioramonti J, Theodorou V. Lactobacillus farciminis treatment attenuates stress-induced overexpression of Fos protein in spinal and supraspinal sites after colorectal distension in rats. Neurogastroenterol Motil 2009 ; 21:567-73.


2005-2008 (selection)

  • Barreau F, Salvador-Cartier C, Houdeau E, Bueno L, Fioramonti J. Long-term alterations of colonic nerve-mast cell interactions induced by neonatal maternal deprivation in rats. Gut 2008 ; 57:582-90.
  • Houdeau E, Moriez R, Leveque M, Salvador-Cartier C, Waget A, Leng L, Bueno L, Bucala R, Fioramonti J. Sex steroid regulation of macrophage migration inhibitory factor in normal and inflamed colon in the female rat. Gastroenterology 2007 ; 132:982-93.
  • Houdeau E, Larauche M, Monnerie R, Bueno L, Fioramonti J. Uterine motor alterations and estrous cycle disturbances associated with colonic inflammation in the rat. Am J Physiol Regul Integr Comp Physiol 2005 ; 288:R630-7.
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Modification date: 08 June 2023 | Publication date: 04 December 2013 | By: EH-RGV