Recruited in 1991 as an engineer in the “Mycotoxicology” team (INRA UR66 laboratory), Jacques was responsible for the analytical development of mycotoxin assays and experiments on mold toxinogenesis (obtaining a PhD in 1994). In 1994, he joined the “Regulation of biotransformations and pharmacokinetics” team to work on the separation and purification of hepatic biotransformation enzymes (cytochromes P450) in livestock species. When the laboratory was reorganized in 1998, he joined the “Pharmacokinetics of antiparasitic drugs” team, studying the in vitro metabolism of endectocides via liver microsomes in target animal species and parasites. He studied the role of membrane transporters (P-glycoproteins) in the fate of endectocides via an in vitro approach (cell lines). In 2010, when the TOXALIM unit was set up, he decided to change direction and joined the “Prevention and promotion of colorectal carcinogenesis through diet” team, focusing on in vitro approaches = creation of murine colorectal epithelial cell lines depleted for key proteins in colorectal carcinogenesis (Apc, Nrf2), participation in the creation of a co-culture model combining murine colonic epithelial cells and murine colonic fibroblasts.