Pascale was recruited to INRA in 1996 (AlimH) to study colonic L enteroendocrine cells (UEPSD, Jouy en Josas). Her research has since led her to address the interactions between “Nutrients and protective factors of the intestinal mucosa” (Inserm U45, Normal and neoplastic intestinal epithelium, Lyon), then the role of environmental factors on the differentiation of intestinal epithelium (Inserm U865, Digestive endocrine tumors, Lyon). Between 2011 and 2019, she characterized the role of dietary lipids in intestinal barrier homeostasis (CarMeN laboratory, Cardiovascular Metabolism Endocrinology and Nutrition, Lyon). The common thread running through her projects is the search for nutritional strategies to compensate for intestinal barrier dysfunction. She has identified beta-casofensine, a new bioactive peptide with high health potential specifically targeting intestinal protection players (Patent EP2430044A1). In 2019, she joined TOXALIM's PPCA team to study the role of interactions between nutritional factors, colonic epithelium and mesenchymal cells in the initiation and progression of colorectal cancer.