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Eric Houdeau et al. shed light on the interactions between bisphenol A and the digestive tract

An article published in "NUTRITION Infos" reported on the work by the team E4-NGN of TOXALIM addressing the interactions between BPA and the gut

If the effects of bisphenol A (BPA), an endocrine disruptor found in food packaging, are known regarding the reproductive system, its impact on the intestine remained unexplored.

The article by Guillaume Frasca, "Bisphenol A: bowel would not be spared" (in French) published in the journal of dietetitians and nutrition professionals "NUTRITION Infos" (February 2012 n°23) reported on the work by the team E4-NGN (Neuro-Gastroenterology & Nutrition) of TOXALIM, led by Vassilia Theodorou, on interactions between BPA, a molecule with estrogen-mimetic properties omnipresent in our daily life, and the gastrointestinal tract, which represents the major interface of our body with its environment.

  • The author based its paper on an interview with Eric Houdeau, member of the team that first demonstrated the effects of BPA on intestinal functions, including disruption of water and electrolyte exchanges at the level of the gut epithelium.
  • This work also helped to highlight the particular sensitivity of the individual to BPA during the perinatal period, by oral contamination by maternal route, whose pathophysiological effects (susceptibility to inflammation ...) will manifest, much later, in adults.

Eric Houdeau actively contributes to the societal debate on endocrine disruptors and food toxicology, and frequently participates in public events and / or regional or national television round-tables in its field of competence.

En savoir plus:Toxalim Actualités ; Fiche Presse Info INRA

See also

Publications citées dans l'article de NUTRITION Infos:

  • Cravedi JP et al. Le concept de perturbation endocrinienne et la santé humaine. Médecine/sciences. 2007;23:198-204.
  • Calafat AM et al. Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population. Environ Health perspect. 2005;113:391-5.
  • Braniste V et al. impact of oral bisphenol A at reference doses on intestinal barrier function and sex differences after perinatal exposure in rats. PNAS. 2010;107:448-53.
  • Braniste V et al. Oestradiol decreases colonic permeability through oestrogen receptor beta- mediated up-regulation of occludin and junctional adhesion molecule-A in epithelial cells. J Physiol. 2009;587:3317-28.
  • Braniste V et al. Bisphenol A in the Gut: Another Break in the Wall? in Multi-System Endocrine Disruption. 2011:127-144.
  • Houdeau E. perturbateurs endocriniens et contamination orale: l'intestin oublié. Médecine & Longévité. 2009;3:85-93.
  • Chung E et al. Effects of bisphenol A and triclocarban on brain-specific expression of aromatase in early zebrafish embryos. PNAS. 2011;108:17732-37.

Publication date : 10 February 2012 | Redactor : RGV